Primary sclerosing cholangitis: Updates in diagnosis and therapy

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Jan 7, 2005; 11(1): 7-16
Published online Jan 7, 2005. doi: 10.3748/wjg.v11.i1.7

Table 3 Regimens and effects of UDCA for PSC therapy.

Regimen		Assessment	Outcome	References
Low doses (single administration)	8-13 mg/(kg·d)	Liver biochemistry	Improved	[92]
	8-13 mg/(kg·d)	Histology, symptoms, survival	Ineffective
	13-15 mg/(kg·d)	Liver biochemistry	Improved	[90]
	13-15 mg/(kg·d)	Histology, symptoms, survival	Ineffective
Low doses (multiple administration)¹	10-12 mg/(kg·d) t.i.d.	Liver biochemistry	Improved	[93]
	10-12 mg/(kg·d) t.i.d.	Histology, symptoms	No progression
	20 mg/(kg·d)	Liver biochemistry	Improved	[94]
	20 mg/(kg·d)	Histology	Improved
High doses	25-30 mg/(kg·d)	ERCP	No progression
		Liver biochemistry	Improved
		Mayo risk score and survival at 4 yr	Improved	[95]
Combination	UDCA 650 mg/d + azathioprine 1-1.5 mg/(kg·d)+ prednisolone 1-10 mg/(kg·d)	Liver biochemistry	Improved
		Histology	Improved	[96]
		ERCP	Improved

¹Comparable effects for multiple vs single administration.

Citation: Portincasa P, Vacca M, Moschetta A, Petruzzelli M, Palasciano G, van Erpecum KJ, van Berge-Henegouwen GP. Primary sclerosing cholangitis: Updates in diagnosis and therapy. World J Gastroenterol 2005; 11(1): 7-16
URL: https://www.wjgnet.com/1007-9327/full/v11/i1/7.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i1.7

Portincasa P, Vacca M, Moschetta A, Petruzzelli M, Palasciano G, van Erpecum KJ, van Berge-Henegouwen GP. Primary sclerosing cholangitis: Updates in diagnosis and therapy. World J Gastroenterol 2005; 11(1): 7-16 [PMID: 15609388 DOI: 10.3748/wjg.v11.i1.7]

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