Effects of tumor necrosis factor, endothelin and nitric oxide on hyperdynamic circulation of rats with acute and chronic portal hypertension

Table 2 Effects of anti-rat TNFa and L-NMMA on levels of TNFa, ET-1 and hepatic NO and NOS activity in PVL and cPHT rats

Groups	TNFα (pg/mL)	ET-1 (pg/mL)	NO (µmol/L)	NOS (u/mg·prot)
Control	48.67 ± 32.29	8.72 ± 0.79	113 ± 15	0.9 ± 0.03
cPHT	477.67 ± 83.8ac	14.33 ± 4.42	278.41 ± 20.11ac	1.81 ± 0.06ac
cPHT+anti-rat TNFα	15.17 ± 18.79a	14.33 ± 4.42	190.61 ± 10.9a	1.39 ± 0.04a
cPHT+L-NMMA	-	-	119.18 ± 11.51e	4.92 ± 0.03e
PVL72 h	416 ± 48ag	13.1 ± 3.2	215.49 ± 12.75ag	1.67 ± 0.16ag
PVL72 h+anti-rat TNFα	14 ± 14a	13.5 ± 2.6	178.59 ± 14.61a	1.34 ± 0.09a
PVL72 h+L-NMMA	-	-	104.61 ± 18i	0.95 ± 0.08i

^aP < 0.05 vs control,

^cP < 0.05 cPHT group compared with cPHT+anti-rat TNFα and cPHT+L-NMMA groups respectively,

^eP < 0.05 cPHT+anti-rat TNFα compared with cPHT+L-NMMA groups,

^gP < 0.05 PVL72 h group compared with PVL72 h+anti-rat TNFα and PVL72 h+L-NMMA groups respectively,

ⁱP < 0.05 PVL72 h+anti-rat TNFα compared with PVL72 h+L-NMMA.