Expression of HIF-2α/EPAS1 in hepatocellular carcinoma

Table 1 Correlation between HIF-2α/EPAS1 and clinicopathological features of HCC patients

Variant	HIF-2α/EPAS1 expression (No of cases)			No of cases 97	Significance
	-	+	++
Pathological grade
Grade I	9	4	3	16	NS
Grade II	23	8	7	38
Grade III-IV	15	7	221	43
Tumor size
2	22	3	8	33
2 - 5	16	14	13	43	0.001a
> 5	9	2	10	21
Cirrhosis
With	27	9	17	53	NS
Without	20	10	14	44
Capsule formation
With	8	1	9	18	NS
Without	39	18	22	79
Capsule infiltration
With	3	3	10	16	0.011a
Without	44	16	21	81
Portal vein invasion
With	15	15	18	48	0.001a
Without	32	4	13	49
Necrosis
With	19	12	23	54	0.010a
Without	28	7	8	43

^aP < 0.05 vs the expression of HIF-2α/EPAS1 was significant in HCC tissues with capsule infiltration, portal vein invasion, necrosis, and tumor size. NS, not significant.