Expression of Egr-1, c-fos and cyclin D1 in esophageal cancer and its precursors: An immunohistochemical and in situ hybridization study

Table 2 Association of expression of c-fos and cyclin D1mRNAs and their proteins with differentiation degree of cancer tissues

Groups	n	c-fos expression								cyclin D1 expression
		ISH				IHC				ISH				IHC
		-	+	++	+++	-	+	++	+++	-	+	++	+++	-	+	++	+++
Squamous carcinoma
Grade I	23	10	4	5	4	6	4	4	9	13	6	4	0	13	4	5	1
Grade II	33	14	7	8	4	16	3	5	9	17	7	6	3	19	6	5	3
Grade III	12	9	0	2	1	10	1	0	1	3	0	3	6	3	1	2	6b

^bP < 0.01, χ² = 11.256, compared with squamous cell carcinoma grades I and II.