Activation of human colon mast cells through proteinase activated receptor-2

Table 1 Effects of tc-LIGRLO, tc-OLRGIL, anti-IgE and cal-cium ionophore A23187 (CI) on tryptase and histamine release from colon mast cells following 30 min incubation period

Concentration of stimulus		Tryptase (ng/mL)	Histamine (ng/mL)
Buffer alone		8.2 ± 0.6	9.5 ± 1.7
tc-LIGRLO	100 µmol/mL	22 ± 3.0a	17 ± 1.3a
tc-OLRGIL	100 µmol/mL	8.4 ± 2.8	10 ± 1.9
Anti-IgE	10 µg/mL	19 ± 4.1a	19 ± 4.8a
CI	1.0 µg/mL	13 ± 0.6a	34 ± 4.3a

The values shown are mean ± SEM for four separate experiments performed in duplicate.

^aP < 0.05 compared with buffer alone group (paired Student’s t test).