Replication and gene expression of mutant hepatitis B virus in a transgenic mouse containing the complete viral genome with mutant s gene

Figure 2 Immunohistochemical analysis of HBsAg and HBcAg in the liver. A: Presence of cytoplasmic HBsAg in almost all of hepatocytes in immunohistochemical analysis of the liver of an 6-week-old male mouse. Magnification, × 100. B: Cytoplasmic HBcAg in centrilobular region hepatocytes surrounding the central veins. Magnification, × 200. C: Nuclear HBcAg scattering widely throughout the hepatic lobule. Magnification, × 100.