A novel mouse model for colitis-associated colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sulfate sodium

Figure 4 Immunohistochemistry of β -catenin and p53 in dys-plastic lesions found in the colon of mice from group A. A: Control colon. β -catenin was expressed exclusively on the cell membrane. No cytoplasmic or nuclear staining was observed, B: Dysplasia cells expressed strong cytoplasmic and partly nuclear staining of β -catenin while other adjacent dys-plastic cells showed membrane pattern of β -catenin, C: Le-sions of early invasive cancer showing strong nuclear and cytoplasmic staining of β -catenin, D: No nuclear expression of p53 in lesions with high-grade dysplasia was observed. Original magnification, × 40.