Effects of narcotic analgesic drugs on human Oddi’s sphincter motility

Table 3 Manometric data before and after administration of Ap-237 in 10 patients (mean ± SD)

	Before Ap-237	10 min after Ap-237	20 min after Ap-237
	administration (n = 10)	administration (n = 10)	administration (n = 10)
Sphincter of Oddi basal pressure (mmHg)	6.42 ± 5.10	11.33 ± 9.39a	11.34 ± 8.40a
Amplitude of phasic contractions (mmHg)	52.56 ± 30.99	87.03 ± 51.72c	50.06 ± 29.11
Frequency of phasic contractions (n/min)	5.62 ± 1.34	7.72 ± 2.16e	9.28 ± 3.98f
Common bile duct pressure (mmHg)	4.20 ± 3.97	4.82 ± 2.30	3.25 ± 2.30

^aP,

^cP,

^eP < 0.05,

^fP < 0.01 vs themselves, n represents the number of patients involved in the research.