Safety of Curcuma aromatica oil gelatin microspheres administered via hepatic artery

Table 5 Changes in respiration, blood pressure and ECG in dogs at different time points after CAO-GMS interventional therapy (mean ± SD)

Time point	Dosage	Number of rats	Respiration frequency (/min)	Heart rate (/min)	Blood pressure (mmHg)
					Systolic	Diastolic
Preoperation	0.10	6	19.0 ± 5.2	219.0 ± 22.7	142.5 ± 9.0	112.7 ± 9.1
	0.03	6	13.5 ± 4.9	196.0 ± 28.5	144.7 ± 12.2	116.2 ± 9.8
30 min postoperative	0.10	6	20.5 ± 6.7	214.7 ± 19.1	142.7 ± 7.3	113.0 ± 8.6
	0.03	6	14.0 ± 4.9	198.3 ± 17.7	146.3 ± 11.3	118.8 ± 12.6
60 min postoperative	0.10	6	19.7 ± 7.7	211.5 ± 18.7	142.3 ± 6.4	113.5 ± 8.1
	0.03	6	12.3 ± 3.4	194.0 ± 16.6	144.0 ± 10.7	119.2 ± 13.6
120 min postoperative	0.10	6	19.5 ± 7.8	211.7 ± 25.0	142.3 ± 10.0	114.0 ± 10.7
	0.03	6	15.3 ± 5.5	193.7 ± 20.2	145.0 ± 9.1	118.8 ± 9.2
180 min postoperative	0.10	6	20.3 ± 8.9	209.3 ± 30.2	141.5 ± 12.3	114.5 ± 13.1
	0.03	6	16.8 ± 6.8	193.7 ± 21.6	143.8 ± 9.5	119.2 ± 9.5