A candidate DNA vaccine elicits HCV specific humoral and cellular immune responses

doi:10.3748/wjg.v10.i17.2488

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Sep 1, 2004 (publication date) through Apr 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Viral Hepatitis

World J Gastroenterol. Sep 1, 2004; 10(17): 2488-2492
Published online Sep 1, 2004. doi: 10.3748/wjg.v10.i17.2488

Table 1 Anti-HCV titers1 after the third injection

Vaccine	Anti-E1 titers
Vaccine	1	2	3	4	5
pSecTagB/sE1 + pSecTagB/sE2²	320	40	Dead animal	320	320
pSecTagB/sE1 + pSecTagB/sE2 + CpG³	80	80	Dead animal	80	80
	Anti-E2 titers
	1	2	3	4	5
pSecTagB/sE1 + pSecTagB/sE2²	160	160	Dead animal	1280	1280
pSecTagB/sE1 + pSecTagB/sE2 + CpG³	160	160	Dead animal	160	1280

¹Titers were determined as described in Materials and Methods. Serial dilution of anti-sera started from 1:40, thus titers lower than 40 were not determined and considered 0.

²The cutoff value was established as mean A of sera from the control mice vaccinated with pSecTagB.

³The cutoff value was established as mean A of sera from the control mice vaccinated with pSecTagB + CpG.

Citation: Zhu LX, Liu J, Ye Y, Xie YH, Kong YY, Li GD, Wang Y. A candidate DNA vaccine elicits HCV specific humoral and cellular immune responses. World J Gastroenterol 2004; 10(17): 2488-2492
URL: https://www.wjgnet.com/1007-9327/full/v10/i17/2488.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i17.2488