Genotype and phylogenetic characterization of hepatitis B virus among multi-ethnic cohort in Hawaii

Table 3 Clinical and virological characteristics in carriers of genotype C with C-1858 or T-1858

		Mutation n(%)
		C-1858 (n = 12)	T-1858 (n = 26)
Age (mean ± SD, yr)		41.7 ± 13.0	43.5 ± 11.6
Gender (male:female)		9:3	12:14
Race	Asian
	Mainland Chinese	3(30)	7(70)
	Filipino	0(0)	2(100)
	Taiwanese	0(0)	2(100)
	Hong Kong	3(38)	5(63)
	Vietnamese	2(67)	1(33)
	Korean	1(14)	6(86)
	Japanese	0(0)	1(100)
	Micronesian	2(100)	0(0)
	Polynesian	0(0)	0(0)
	Caucasian	1(50)	1(50)
Liver disease	ASC	2(17)	10(29)
	CH	8(67)	21(60)
	LC	1(8)	1(3)
	HCC	1(8)	3(9)
Laboratory finding	HBeAg (+)	10(83)	16(62)
	AST (U/L)	34.9 ± 17.0	63.8 ± 97.6
	ALT (U/L)	23.2 ± 11.2	43.8 ± 71.3
	ALP (U/L)	334.6 ± 186.3	324.9 ± 157.0
	γ-GTP (U/L)	87.8 ± 167.3	57.2 ± 48.4
CP mutation	Double mutation	6(50)	16(62)
PC mutation	A-1896	0(0)	8(31)

ASC: Asymptomatic carrier; CH: Chronic hepatitis; LC: Liver cirrhosis; HCC: Hepatocellular carcinoma; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; γ -GTP: γ -glutamyl transpeptidase; CP: Core promoter; PC: Precore.