L-arginine-induced experimental pancreatitis

Table 2 Changes of inflammatory mediator levels in Arg-induced acute pancreatitis

Mediator	Dose of Arg/100 g bm	Effect	Reference
MDA	2 × 250 mg	↑	Czakó et al., 1998
NSG, MDA	300 mg	↑	Rakonczay et al., 2003
Protein carbonyl	300 mg	↑	Rakonczay et al., 2003
Mn-, Cu, Zn-SOD	2 × 250 mg	↓	Czakó et al., 1998
Catalase	2 × 250 mg	↓	Czakó et al., 1998
glutathione peroxidase	2 × 250 mg	↓↑	Czakó et al., 1998
Serum TNF-α, IL-6	2 × 250 mg	↑	Czakó et al., 2000
Serum TNF-α, IL-1, IL-6	2 × 230 mg	↑	Rakonczay et al., 2002
Pancreatic IL-1β	300 and 400 mg	↑	Rakonczay et al., 2003
Pancreatic TNF-α	300 and 400 mg	↑	Rakonczay et al., 2003
Pancreatic cNOS	2 × 250 mg	↓↑	Takács et al., 2002
Pancreatic iNOS	2 × 250 mg	↑	Takács et al., 2002
CCK	2 × 250 mg	↑	Czakó et al., 2000

↓: Decreased activity, ↑: Increased activity, Arg: L-arginine, MDA: Malondialdehyde, NSG: Nonprotein sulfhydryl group, SOD: Superoxide dismuthase, TNF: Tumor necrosis factor, IL: Interleukin, CCK: Cholecystokinin-octapeptide.