Association of differentially expressed genes with activation of mouse hepatic stellate cells by high-density cDNA mircoarray

doi:10.3748/wjg.v10.i11.1600

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Jun 1, 2004 (publication date) through May 10, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 1, 2004; 10(11): 1600-1607
Published online Jun 1, 2004. doi: 10.3748/wjg.v10.i11.1600

Table 4 Part of down-regulated genes in the activated HSC

GenBank accession number	Gene name	Ratio (Cy5/Cy3)	Potential gene function
D49949	mRNA for IGIF precursor poly-peptide in (Interleukin 18), complete cds	0.065	In the development of Th1 cells and tissue injury inflammatory reaction
U63146	Retinal binding protein (RBP) mRNA	0.125	Retinoid storage and metabolism
AF035644	Potentially prenylated protein tyrosine phosphatase mPRL-2 mRNA, complete cds	0.226	Cellular regulation
X58287	mR-PTPu gene for protein tyrosine phosphatase, receptor-type M	0.280	Cellular regulation
AF033381	Betaine homocysteine methyl transferase (BHMT) mRNA, complete cds	0.299	A key liver enzyme that is important for homocysteine homeostasis
M75720	Alpha-1 serine protease inhibitor 3 mRNA, complete cds	0.308	Anti-inflammatory effect
U20497	P19 protein mRNA, complete cds	0.324	CDK4&CDK6 inhibitor, cell cycle inhibitor
D85596	AMP deaminase H-type, complete cds	0.339	Involved in the biosynthesis, inter-conversion and degradation of purine compounds
Y10138	Gene encoding prostaglandin D synthase	0.361	A PGD producing enzyme and a retinoid transporter
NM_013498	CAMP response element modulator (CREM) mRNA	0.366	Down-regulator of CAMP-induced transcription
U67187	G protein signaling regulator RGS2 (rgs2) mRNA, complete cds	0.369	Negatively regulate G-coupled receptor function
AF023919	PK-120 precursor (itih-4) mRNA, complete cds	0.421	Inter-alpha-trypsin-inhibitor H4, is a potential regulator for ECM proteins
AF077950	Protein inhibitor of activated STAT protein PIAS 1 mRNA, complete cds	0.433	Inhibition of STAT-1-mediated gene activation
M75718	Alpha-1 protease inhibitor 4 mRNA, complete cds	0.437	Anti-inflammatory activity
D38046	mRNA for type II DNA topoisomerase beta isoform, complete cds	0.445	An essential enzyme that alters DNA topology which is important for cell survive and apoptosis
AF073996	myotubularin (Mtm1) mRNA complete cds	0.464	Subfamily of protein tyrosine phosphatases

Citation: Liu XJ, Yang L, Luo FM, Wu HB, Qu-Qiang. Association of differentially expressed genes with activation of mouse hepatic stellate cells by high-density cDNA mircoarray. World J Gastroenterol 2004; 10(11): 1600-1607
URL: https://www.wjgnet.com/1007-9327/full/v10/i11/1600.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i11.1600