Increased nociceptin/orphanin FQ plasma levels in hepatocellular carcinoma

Table 1 Profile of patients with HCC and plasma N/OFQ levels

	Age(yr)	Gender	Aetiology	AFP(ng/mL)	Tumor sizein UH	Uni-nod.	Multi-nod.	BCLCst.cl.	CLIPcl.	Bi(mg/dL)	ALP(U/L)	GGT(U/L)	Ascites	C-P	N/OFQ(pg/mL)
1	80	M	Alcoholic	937	15 × 11 cm	+		A 4	3	1.72	306	102	-	A	108.39
2	64	M	Alcoholic	1 385.9	5 × 7 × 6 cm	+		A 1	1	1.92	242	107	-	A	95.02
3	60	M	Alcoholic	89	5 -15 mm and 3 cm		+	B	2	1.07	2 169	1 000	-	B	96.05
4	62	M	Alcoholic	91	1-1.5 cm and 3.5 cm		+	B	2	1.12	2 038	995	-	B	104.17
5	80	M	Alcoholic	937	15 × 11 cm	+		A 1	3	1.71	306	102	-	A	111.59
6	70	M	Alcoholic	459	7 × 6 cm	+		A 1	2	0.78	192	68	-	A	111.51
7	59	M	Alcoholic	7.7	23 mm	+		D	2	8.32	44.3	97	-	C	128
8	66	M	Alcoholic	2	1.5 cm	+		A 1	0	1.25	192	24	-	A	81.6
9	48	F	HCV	15	6 × 6 cm	+		A 4	1	5.75	1 766	253	-	B	90.41
10	66	M	HCV	171	two, 2 × 2 cm lesion		+	A 4	1	2.55	460	232	-	A	89.81
11	76	M	HCV	9	6 × 7 cm + 5 × 4 cm		+	D	4	13.91	834	276	+	C	114.65
12	78	M	HCV	350	5 × 6 ccm	+		A 1	0	0.68	270	37	-	A	114.7
13	48	F	HCV	13	21 × 20 mm		+	B	1	1.36	474	1 060	-	A	128
					and 16 × 21 mm
14	81	M	HCV	1 050	8 × 10 cm	+		A 4	3	3	569	517	-	A	98.31
15	66	M	HBV	6	4 × 4.5 cm	+		D	2	3.35	442	199	+	C	106.03
16	45	F	WD	5	60 × 46 mm	+		A 4	1	0.42	910	212	+	B	128
17	68	F	PBC	3 480	11 × 7.5 cm	+		D	5	4.79	1 856	960	+	C	172.2
18	32	F	Unknown	1 050	100 × 85 × 180 mm	+		A 4	3	0.34	233	24	-	-	85.5

AFP = alpha fetoprotein, BCLC st. cl. = Barcelona Clinic Liver Cancer (BCLC) staging classification, CLIP cl. = Cancer of the Liver Italian Program Group (CLIP) scoring system, Bi=Serum total bilirubin, ALP = alkaline phosphatase, GGT = gamma glutamyl transferase, C-P = Child-Pugh score, N/OFQ = nociceptin/orphanin FQ.