Trends in iron deficiency anemia research 2001-2020: A bibliometric analysis

Table 1 Top 15 journals ranked by number of papers published, and corresponding impact factors

Journal	Records	Impact factor
Journal of nutrition	107	4.281
PLoS One	81	2.740
World Journal of Gastroenterology	76	3.665
American Journal of Clinical Nutrition	75	6.766
Nutrients	67	4.546
Pediatrics	50	5.359
Food	48	1.485
Journal of Pediatric Hematology Oncology	48	1.016
Helicobacter	44	4.000
American	39	6.973
Blood	39	17.543
Digestive Diseases and Sciences	35	2.751
Pediatric Hematology and Oncology	34	1.232
Biological	33	2.639
Journal of Pediatric Gastroenterology and Nutrition	33	2.937

Table 2 Top 25 keywords of each 5-year interval between 2001-2020 color coded to the clusters identified in Figure 4

2001	2006		2011	2016
Iron-deficiency anemia3	Iron-deficiency anemia3		Iron-deficiency anemia3	Iron-deficiency anemia3
Anemia1	Anemia1		Anemia1	Anemia1
Children1	Iron deficiency anemia1		Iron deficiency anemia1	Iron deficiency anemia1
Iron deficiency anemia1	Children1		Children1	Prevalence1
Iron deficiency2	Iron deficiency2		Iron deficiency2	Children1
Iron5	Prevalence1		Prevalence1	Iron deficiency2
Prevalence1	Diagnosis3		Iron5	Diagnosis3
Serum ferritin5	Iron5		Diagnosis3	Management3
Ferritin5	Supplementation1		Supplementation1	Iron5
Supplementation1	Infants1		Hepcidin5	Supplementation1
Diagnosis3	Serum ferritin5		Management3	Pregnancy1
Absorption2	Women1		Hemoglobin1	Hepcidin5
Deficiency5	Hemoglobin1		Pregnancy1	Hemoglobin1
Infants1	Absorption2		Ferritin5	Risk3
Erythropoietin4	Deficiency5		Intravenous iron4	Intravenous iron4
Pregnancy1	Hepcidin5		Women1	Women1
Women1	Therapy4		Deficiency anemia1	Ferritin5
Therapy4	Iron-deficiency1		Disease3	Oral iron4
Hemoglobin1	Growth1		Inflammation5	Health1
Eradication3	Helicobacter pylori3		Risk3	Disease3
Serum transferrin receptor5	Pregnancy1		Association3	Infants1
Helicobacter pylori3	Disease3		Metabolism1	Deficiency5
Iron-deficiency1	Risk3		Infants1	Iron-deficiency1
Deficiency anemia1	Celiac disease3		Serum ferritin5	Deficiency anemia1
Disease3	Expression5		Deficiency5	Ferric carboxymaltose4
Number of keywords
Red
11	12		11	12
Purple
2	2		1	1
Blue
5	5		6	5
Yellow
2	1		1	3
Green
5	5		6	4
New items in each quartile
(None)		Serum ferritin5	Management3	Oral iron4
		Hepcidin5	Intravenous iron4	Health1
		Growth1	Inflammation5	Ferric carboxymaltose4
		Risk3	Association3
		Celiac disease3	Metabolism1
		Expression5	Infants1

¹Red.

²Purple.

³Blue.

⁴Yellow.

⁵Green.

Summary shows the number of keywords in each 5-year quartile by cluster and a list of the keywords appearing for the first time in the top-25 list for each quartile.

Table 3 The top 10 cited papers published for the entire period 2001-2020, and the top 10 cited papers published in each 5-year interval within the study period

2001-2020
Ref.	Title	Journal	Year	Volume	Start page	End page	Times cited	Topic
Vos et al[14], 2012	Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010	Lancet	2012	380	2163	2196	4084	1
Malfertheiner et al[34], 2007	Current concepts in the management of Helicobacter pylori infection: the maastricht III consensus report	Gut	2007	56	772	781	1481	3
Bhutta et al[44], 2008	Maternal and Child Undernutrition 3 - What works? Interventions for maternal and child undernutrition and survival	Lancet	2008	371	417	440	1147	4
Darmon and Drewnowski[19], 2008	Does social class predict diet quality?	American Journal of Clinical Nutrition	2008	87	1107	1117	1061	1
Walker et al[45], 2007	Child development in developing countries 2 - Child development: risk factors for adverse outcomes in developing countries	Lancet	2007	369	145	157	1033	4
Chey and Wong[39], 2007	American college of gastroenterology guideline on the management of Helicobacter pylori infection	American Journal of Gastroenterology	2007	102	1808	1825	830	3
Guralnik et al[20], 2004	Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia	Blood	2004	104	2263	2268	793	1
Ludvigsson et al[40], 2013	The Oslo definitions for coeliac disease and related terms	Gut	2013	62	43	52	790	3
Rubio-Tapia et al[41], 2013	ACG Clinical Guidelines: Diagnosis and Management of Celiac Disease	American Journal of Gastroenterology	2013	108	656	676	788	3
Hill et al[35], 2005	Guideline for the diagnosis and treatment of celiac disease in children: Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition	Journal of Pediatric Gastroenterology and Nutrition	2005	40	1	19	752	4
2001-2005
Guralnik et al[20], 2004	Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia	Blood	2004	104	2263	2268	793	1
Hill et al[35], 2005	Guideline for the diagnosis and treatment of celiac disease in children: Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition	Journal of Pediatric Gastroenterology and Nutrition	2005	40	1	19	752	4
Grantham-McGregor and Ani[23], 2001	A review of studies on the effect of iron deficiency on cognitive development in children	Journal of Nutrition	2001	131	649S	666S	736	1
Pennazio et al[33], 2004	Outcome of patients with obscure gastrointestinal bleeding after capsule endoscopy: Report of 100 consecutive cases	Gastroenterology	2004	126	643	653	688	3
Nicolas et al[28], 2002	Severe iron deficiency anemia in transgenic mice expressing liver hepcidin	Proceedings of The National Academy of Sciences of The United States of America	2002	99	4596	4601	694	2
Haas and Brownlie[2], 2001	Iron deficiency and reduced work capacity: A critical review of the research to determine a causal relationship	Journal of nutrition	2001	131	676S	688S	573	1
Dubé et al[22], 2005	The prevalence of celiac disease in average-risk and at-risk Western European populations: A systematic review	Gastroenterology	2005	128	S57	S67	427	1
Ohgami et al[31], 2005	Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells	Nature Genetics	2005	37	1264	1269	394	2
Beard and Connor[24], 2003	Iron status and neural functioning	Annual Review of Nutrition	2003	23	41	58	383	1
Graham et al[37], 2005	Visible small-intestinal mucosal injury in chronic NSAID users	Clinical Gastroenterology and Hepatology	2005	3	55	59	391	4
2006-2010
Malfertheiner et al[34], 2007	Current concepts in the management of Helicobacter pylori infection: the maastricht III consensus report	Gut	2007	56	772	781	1481	3
Bhutta et al[44], 2008	Maternal and Child Undernutrition 3 - What works? Interventions for maternal and child undernutrition and survival	Lancet	2008	371	417	440	1147	4
Darmon and Drewnowski[19], 2008	Does social class predict diet quality?	American Journal of Clinical Nutrition	2008	87	1107	1117	1061	1
Walker et al[45], 2007	Child development in developing countries 2 - Child development: risk factors for adverse outcomes in developing countries	Lancet	2007	369	145	157	1033	4
Chey and Wong[39], 2007	American college of gastroenterology guideline on the management of Helicobacter pylori infection	American Journal of Gastroenterology	2007	102	1808	1825	830	3
Levin and Rocco[38], 2006	KDOQI clinical practice guidelines and clinical practice recommendations for anemia in chronic kidney disease - Foreword	American Journal of Kidney Diseases	2006	47	S9	S145	565	4
Lozoff et al[25], 2006	Long-lasting neural and behavioral effects of iron deficiency in infancy	Nutrition Reviews	2006	64	S34	S43	532	1
Rostom et al[46], 2006	American Gastroenterological Association (AGA) Institute Technical Review on the Diagnosis and Management of Celiac Disease	Gastroenterology	2006	131	1981	2002	514	3
Ganz et al[29], 2008	Immunoassay for Human Serum Hepcidin	Blood	2008	112	4292	4297	502	2
Plum et al[26], 2010	The Essential Toxin: Impact of Zinc on Human Health	International Journal of Environmental Research and Public Health	2010	7	1342	1365	484	5
2011-2015
Vos et al[14], 2012	Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010	Lancet	2012	380	2163	2196	4084	1
Ludvigsson et al[40], 2013	The Oslo definitions for coeliac disease and related terms	Gut	2013	62	43	52	790	3
Rubio-Tapia et al[41], 2013	ACG Clinical Guidelines: Diagnosis and Management of Celiac Disease	American Journal of Gastroenterology	2013	108	656	676	788	3
Kassebaum et al[18], 2014	A systematic analysis of global anemia burden from 1990 to 2010	Blood	2014	123	615	624	623	1
Walker et al[47], 2011	Child Development 1 Inequality in early childhood: risk and protective factors for early child development	Lancet	2011	378	1325	1338	621	1
Camaschella[48], 2015	Iron-Deficiency Anemia	New England Journal of Medicine	2015	372	1832	1843	402	Multiple
Chey et al[49], 2015	Irritable Bowel Syndrome A Clinical Review	Jama-journal of The American Medical Association	2015	313	949	958	378	3
Balarajan et al[21], 2011	Anaemia in low-income and middle-income countries	Lancet	2011	378	2123	2135	353	1
Pennazio et al[33], 2004	Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline	Endoscopy	2015	47	352	376	317	3
Goodnough et al[42], 2011	Detection, evaluation, and management of preoperative anaemia in the elective orthopaedic surgical patient: NATA guidelines	British Journal of Anaesthesia	2011	106	13	22	303	3
2016-2020
Chey et al[50], 2017	ACG Clinical Guideline: Treatment of Helicobacter pylori Infection	American Journal of Gastroenterology	2017	112	212	239	324	3
Amieva and Peek[51], 2016	Pathobiology of Helicobacter pylori-Induced Gastric Cancer	Gastroenterology	2016	150	64	78	224	4
Kyu et al[52], 2016	Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013 Findings From the Global Burden of Disease 2013 Study	Jama Pediatrics	2016	170	267	287	214	1
Girelli et al[30], 2005	Hepcidin in the diagnosis of iron disorders	Blood	2016	127	2809	2813	147	2
Kassebaum[53], 2016	The Global Burden of Anemia	Hematology-oncology Clinics of North America	2016	30	247	308	141	1
Trenkwalder et al[54], 2016	Restless legs syndrome associated with major diseases A systematic review and new concept	Neurology	2016	86	1336	1343	117	4
Xie et al[27], 2016	Advances on Bioactive Polysaccharides from Medicinal Plants	Critical Reviews in Food Science and Nutrition	2016	56	S60	S84	112	5
Enns et al[55], 2017	Clinical Practice Guidelines for the Use of Video Capsule Endoscopy	Gastroenterology	2017	152	497	514	111	3
Froessler et al[36], 2018	The Important Role for Intravenous Iron in Perioperative Patient Blood Management in Major Abdominal Surgery A Randomized Controlled Trial	Annals of Surgery	2016	264	41	46	98	4
Vasanawala et al[56], 2016	Safety and technique of ferumoxytol administration for MRI	Magnetic Resonance in Medicine	2016	75	2107	2111	93	3 and 4

For the Topic column, the following numbers correspond to these topics: (1) Epidemiologic aspects of iron deficiency anemia; (2) Biochemical aspects of iron deficiency anemia; (3) Clinical evaluation of causes of iron deficiency anemia; (4) Causes of iron deficiency anemia; and (5) Bioavailability of dietary iron.