Systematic Reviews
Copyright ©The Author(s) 2021.
World J Meta-Anal. Apr 28, 2021; 9(2): 193-207
Published online Apr 28, 2021. doi: 10.13105/wjma.v9.i2.193
Table 3 Studies comparing coronavirus disease 2019 patients with severe vs non-severe disease
Ref.
Country
Patients with severe disease (% of total)
Setting
Definition of SEVERE disease
Definition of liver Injury
Evaluated parameters
Summary of main findings
NOS
Cai et al[67]China58 (19.5)Hospitalized patientsRadiography supporting severe diseaseALT OR AST > 3 times ULN or GGT or TBIL > 2 times ULNWBC, ANC, ALC, DDIMLFT significantly elevated in severe cohort at admission8
Jiang et al[68]China27 (20.6)Hospitalized patientsChinese National Health Committee criteria (see ref[82])AST OR ALT OR ALP OR TBIL > 5 times ULNWBC, ANC, ALC, PLTS, HGBLiver injury in 81% of severe cohort over course of hospitalization; slow recovery from liver injury compared to other cohorts7
Lei et al[69]China48 Severe cohortHospitalized patientsNational Health Commission of the People’s Republic of China and National Administration of Traditional Chinese Medicine of the People’s Republic of China criteria (see ref[83])CT showing liver hypodensity and pericholecystic fat strandingWBC, ALC, PLTSSeverity of COVID-19 disease correlated with liver function7
China48 Critical cohortHospitalized patientsHealth Commission of the People’s Republic of China and National Administration of Traditional Chinese Medicine of the People’s Republic of China criteria (see ref[83])CT showing liver hypodensity and pericholecystic fat strandingWBC, ALC, PLTSSeverity of COVID-19 disease correlated with liver function
Liao et al[70]China29 (15.1)Hospitalized patientsNational Guidelines for 2019 novel coronavirus-associated pneumonia (the fifth revised version)AST OR ALT OR TBIL over ULNWBC, ANC, ALC, HGB, DDIMLiver injury in high percentages of patients from both groups; correlated with inflammatory cytokine levels7
Yang et al[71]China215 (72.9)Hospitalized patientsWHO criteria (see ref[8] from[68])AST > 1.5 times ULNWBC, ANC, ALC, PLT, DDIM, PTAST and GGT levels correlated with disease severity7