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Copyright ©2013 Baishideng Publishing Group Co.
World J Pharmacol. Dec 9, 2013; 2(4): 107-114
Published online Dec 9, 2013. doi: 10.5497/wjp.v2.i4.107
Table 1 Immune cell types that are regulated by aryl hydrocarbon receptor
Cell typeAhR-dependent effectRef.
ThAbsence of AhR increases secretion of inflammatory cytokines (IFN-γ, IL-12)[71]
TregActivation of AhR by TCDD increases their proliferation[58]
Tr1IL-27-induces AhR activity, which in combinatio with c-Maf, suppresses their differentiation[72]
B cellsTCDD enhances IgM secretion and inhibits the differentiation of plasma cells[73]
DCsTCDD reduces the number of splenic DCs[74]
MacrophageAhR-STAT1 interactions suppress the activation and differentiation of macrophage, and induces the IgA receptor FcαRI. TCDD reduces CD11a expression.[49,75] [76]
Table 2 Degenerative diseases modified by aryl hydrocarbon receptor
Degenerative diseaseAhR-dependent effectRef.
Experimental autoimmune encephalomyelitisTCDD suppresses the disease by inducing T reg cells FICZ exacerbates the disease[58]
GVHDTCDD prevents the disease by generating T reg cells[46]
ColitisFICZ exacerbates disease[77]
Collagen-induced arthritisAhR exacerbates the diseas[78]
Autoimmune uveoretinitisTCDD suppresses the disease[79]
Spontaneous autoimmune diabetesTCDD suppresses the disease[80]
Experimental multiple sclerosisAhR activation reduces inflammation via Tr1 induction[72]
Experimental lupusInduction of Tr1 by AhR activation stops the inflammatory process[81]
Rheumatoid arthritisAhR activation by TCDD exacerbates the disease[82]