Copyright ©The Author(s) 2023.
World J Pharmacol. Jun 16, 2023; 12(3): 18-24
Published online Jun 16, 2023. doi: 10.5497/wjp.v12.i3.18
Figure 1
Figure 1 Effects of silymarin alone on the pathogenesis and symptoms of depression in a study on dexamethasone-induced mice. 1Indicates significant difference in the group administered silymarin 280 mg/kg only. 2Indicates significant difference in both silymarin 140 mg/kg and 280 mg/kg. 3Activity includes tail suspension and forced swim tests, elevated plus maze, and locomotor activity. ↑ Indicates a significant increase (P < 0.05) relative to dexamethasone-induced mice. ↓ Indicates a significant decrease (P < 0.05) relative to dexamethasone-induced mice. GPx: Glutathione peroxidase; GSH: Glutathione; IL-10: Interleukin-10; MDA: Malondialdehyde; SOD: Superoxide dismutase; TNF- α: Tumor necrosis factor-alpha.