Comparison of next generation sequencing-based and methylated DNA immunoprecipitation-based approaches for fetal aneuploidy non-invasive prenatal testing

Table 1 Validation and verification comparison of the most widely used commercially available non-invasive prenatal testing for trisomy 21

Company	Sequenome	Verinata (Illumina)	Ariosa	Natera
Test	"Materni T21 PLUS"	"Verify"	"Harmony"	"Panorama"
Sensitivity	99.6%-99%	> 99%	100%	> 99%
	(209/212)	(90/90)	(81/81)	(25/25)
Specificity	99.8%	99.8%	99.97%	> 99%
	(1468/1471)	(409/410)	(2887/2888)	(242/242)
False positive	0.2%	0.2%	0.03%	0
	(3/1471)	(1/410)	(1/2888)
No result rate	3.4%	5.8%	4.7%-5.7%	5.4%