Field Of Vision
Copyright ©2013 Baishideng.
World J Med Genet. May 27, 2013; 3(2): 5-8
Published online May 27, 2013. doi: 10.5496/wjmg.v3.i2.5
Table 1 Characters of the methods to detect genomic copy number variations
Fluorescence in situ hybridizationNumbers of the signals correspond to the genomic copy numbersSmall duplications cannot be detected
Quantitative polymerase chain reactionWide dynamic rangePrimer designs are required for each targets
Many samples can be analyzed at once
Multiple ligation probe amplificationMultiple targets can be analyzed at onceOriginal primer designs are required for specific regions
Chromosomal microarray testingAccurate and high resolutionChromosomal structures including balanced translocations cannot be analyzed
Table 2 Characteristics of microduplications
CharacteristicRecurrent microduplicationsRandom microduplications
MechanismNon-allelic homologous recombinationRandom
Mediated by locus control regions
CharacteristicsReciprocal to common deletionsRandom
Uniformed size