基础研究
Copyright ©The Author(s) 2024.
世界华人消化杂志. 2024-01-28; 32(1): 58-70
在线出版 2024-01-28. doi: 10.11569/wcjd.v32.i1.58
表1 螺杆菌属菌株基本信息
菌种宿主寄生部位致病性菌株基因组编号
H. pylori[16]人, 猴, 猫, 狗, 猪, 鼠胃慢性胃炎, 消化性溃疡, 胃淋巴瘤, 胃癌FDAARGOS_298GCF_003050665.1
ATCC 43504GCF_004295525.1
NCTC 11637GCF_900478295.1
B659-C2GCF_003639215.1
280-A-EK1GCF_006337465.1
HUP-B14GCF_000259235.1
83GCF_000213135.1
J99GCF_000008785.1
MT5135GCF_017821535.1
HP14039GCF_003636855.2
LIM-008GCF_016748795.1
HPYGCF_013122115.1
H. mustelae[16]雪貂胃慢性胃炎NCTC12198GCF_900476215.1
H. felis[17]猫, 狗胃慢性胃炎, 胃癌ATCC 49179GCF_000200595.1
H. nemestrinae[18]猴胃NRNRNR
H. cinaedi[19]人, 猫, 狗, 仓鼠肠道急性腹泻, 菌血症DSM 5359GCF_017979495.1
H. fennelliae[19]人, 狗肠道肠炎, 菌血症NCTC11613GCF_900451005.1
H. muridarum[20]鼠胃, 肠道胃炎NCTC12714GCF_900450885.1
H. acinonychis[21]豹胃胃炎NCTC12686GCF_900461455.1
H. canis[22]人, 猫, 狗肝脏, 肠道腹泻, 肝炎CCUG 32756TGCF_008693005.1
H. hepaticus[23]鼠肝肠, 肠道肝炎, 肝癌, 炎症性肠病ATCC 51449GCF_000007905.1
H. pametensis[24]鸟, 猫, 猪肠道NRATCC 51478GCF_000518225.1
H. pullorum[25]人, 鸡肝脏, 肠道胃肠炎, 慢性肝炎CCUG 33837GCF_017979475.1
H. bilis[26]猫, 狗, 人肝脏, 肠道慢性肝炎ATCC 51630GCF_000765785.2
H. bizzozeronii[27]猫, 狗, 鼠胃胃炎CCUG 35545GCA_000263275.1
H. trogontum[28]鼠肠道NRATCC 700114GCF_000765905.2
H. cholecystus[29]仓鼠胆囊胰腺炎, 胆管炎, 肝炎ATCC 700242GCF_003364215.1
H. salomonis[30]猫, 狗胃NRCIP 105607GCF_017979425.1
H. rodentium[31]鼠肠道腹泻ATCC 700285GCF_000687535.1
H. westmeadii[32]人肝脏, 肠道NRNRNR
H. suncus[33]麝胃慢性胃炎NRNR
H. typhlonius[34]鼠肠道盲肠炎MIT 98-6810GCF_000765765.2
H. canadensis[35]人, 鹅肝脏, 肠道腹泻NCTC13221GCF_900450815.1
H. ganmani[36]鼠肝脏, 肠道NRMIT 99-5101GCF_003364315.1
H. winghamensis[37]人肠道腹泻, 胃肠炎2015D-0170GCF_014931175.1
H. cetorum[38]海豚, 鲸鱼胃胃溃疡, 胃炎MIT 99-5656GCF_000259275.1
H. marmotae[39]猫, 土拨鼠肝脏, 肠道肝癌MIT 98-6070GCF_003364255.1
H. cynogastricus[40]狗胃NRNRGCF_900197855.1
H. anseris[41]鹅肠道NRMIT 04-9362GCF_003364335.1
H. brantae[41]鹅肠道NRMIT 04-9366GCF_003364205.1
H. equorum[42]马肠道NRMIT 12-6600GCF_003364175.1
H. suis[43]猴,猪胃食管及胃部炎症, 胃溃疡DSM 19735GCF_017979375.1
H. baculiformis[44]猫,狗胃NRNRGCF_900197685.1
H. heilmannii[45]人, 猫, 狗, 猪胃胃炎, 胃溃疡LMG 26292GCF_017979395.1
H. ailurogastricus[46]猫,狗胃胃炎, 胃溃疡NRGCF_900197675.1
H. jaachi[47]猴胃,肝脏,肠道肝炎, 胆囊炎, 肠炎MIT 09-6949GCF_000763135.2
H. apri[48]野猪胃, 肝脏, 肠道NRNRNR
H. mehlei[49]赤狐胃NRL8bGCF_007280785.1
H. labacensis[49]赤狐胃NRL9GCF_003660285.1
H. vulpis[49]赤狐胃NRL2GCF_003660395.1
NR: 无记录.
表2 螺杆菌属致病物质基因在螺杆菌属细菌基因组中的分布
菌种菌株侵袭因子
毒素
UreaseFlagellinAlpA/BBabASabAOipAHopELPSCagAVacAIceA
H. pyloriFDAARGOS_298+++++++++++
ATCC 43504+++++++++++
NCTC 11637+++++++++++
B659-C2+++---++-++
280-A-EK1++++--++-+-
HUP-B14++++-+++-+-
83++-----++-+
J99+++++++++-+
MT5135++----+++-+
HP14039+++-+-++---
LIM-008++----++---
HPY+++-++++--+
H. acinonychisNCTC12686++-----+---
H. cetorumMIT 99-5656++-----+---
H. suisDSM 19735++-----+---
H. labacensisL9++-----+---
H. bizzozeroniiCCUG 35545++-------+-
H. cynogastricusNR++-----+---
H. felisATCC 49179++-----+---
H. heilmanniiLMG 26292++-----+---
H. baculiformisNR++-----+---
H. vulpisL2++-----+---
H. ailurogastricusNR++-----+---
H. mehleiL8b++-----+---
H. canadensisNCTC13221-+-----+---
H. equorumMIT 12-6600-+-----+---
H. pullorumCCUG 33837-+---------
H. winghamensis2015D-0170-+-----+---
H. rodentiumATCC 700285-+-----+---
H. ganmaniMIT 99-5101-+-----+---
H. cholecystusATCC 700242-+-----+---
H. brantaeMIT 04-9366-+-----+---
H. pametensisATCC 51478-+-----+---
H. mustelaeNCTC12198-+-----+---
H. anserisMIT 04-9362++-----+---
H. jaachiMIT 09-6949++-----+---
H. marmotaeMIT 98-6070++-----+---
H. cinaediDSM 5359++-----+---
H. bilisATCC 51630-+-----+--+
H. canisCCUG 32756++-----+---
H. trogontumATCC 700114-+-----+---
H. hepaticusATCC 51449++-----+---
H. muridarumNCTC12714++-----+---
H. typhloniusMIT 98-6810++-----+---
对于基因在基因组中的分布状态, +: 存在该基因序列, -: 不存在该基因序列.
引文著录: 徐乐, 刘兴, 吴琦, 华召来, 杨菲, 张军峰. 螺杆菌属细菌致病基因系统进化分析. 世界华人消化杂志 2024; 32(1): 58-70