化痰活血扶正方及其拆方后的相关药组对模型大鼠肝纤维化指标的影响

表1 各药组对肝纤维化大鼠模型血清AST、ALT、TP、AIb、GLB的影响 (n = 8)

分组	AST (U/L)	ALT (U/L)	TP (g/L)	AIb (g/L)	GLB (g/L)
Model	126.2 ± 29.80	49.2 ± 6.43	58.8 ± 3.33	25.9 ± 1.13	33.2 ± 2.36
Silybin	195.5 ± 46.63a	101.3 ± 28.09a	51.7 ± 2.64a	23.8 ± 0.63a	27.1 ± 1.56a
HTL	151.6 ± 44.65	76.0 ± 15.76	55.3 ± 2.79	27.1 ± 1.63e	27.3 ± 0.43
HTM	125.3 ± 31.26c	62.8 ± 11.99e	51.5 ± 2.12	25.6 ± 0.79	25.9 ± 1.81
HTH	91.5 ± 19.06e	55.3 ± 10.73e	58.5 ± 4.44d	28.8 ± 2.07e	29.6 ± 2.51
HXHYL	91.8 ± 25.10e	53.6 ± 11.08e	55.9 ± 2.20	27.7 ± 0.86e	29.0 ± 1.23
HXHYM	109.6 ± 21.84d	59.0 ± 9.11e	55.7 ± 1.68	25.8 ± 0.92	30.0 ± 1.63
HXHYH	119.7 ± 26.54d	57.7 ± 11.43e	54.9 ± 2.25	26.1 ± 1.10c	28.8 ± 1.30
FZL	107.6 ± 23.96e	53.8 ± 9.15e	52.4 ± 1.04	24.7 ± 1.78	26.7 ± 2.04
FZM	143.8 ± 28.09	80.4 ± 17.81	52.5 ± 3.27	25.7 ± 1.25	26.4 ± 2.58
FZH	87.2 ± 31.09e	46.4 ± 10.83e	52.8 ± 4.14	27.7 ± 0.64e	25.9 ± 2.12
HTHXF	113.2 ± 43.81c	61.2 ± 23.92e	53.2 ± 3.42	26.9 ± 1.39e	27.5 ± 3.01
ZL	121.8 ± 29.65d	65 ± 19.24d	50.6 ± 2.59	25.1 ± 0.66	25.4 ± 1.95
HTHXF	105.2 ± 29.85e	60.6 ± 9.81e	52.9 ± 1.60	26.6 ± 0.43d	26.1 ± 1.38
ZM	102.8 ± 25.59e	63.0 ± 12.73e	56.6 ± 2.70c	27.5 ± 1.42e	29.1 ± 2.52
HTHXF
ZH

^aP<0.05与正常组比较;

^cP<0.05,

^dP<0.01,

^eP<0.001与模型组比较. AST: 谷草转氨酶; ALT: 谷丙转氨酶; TP: 总蛋白; AIb: 白蛋白; GLB: 球蛋白.

表2 各药组对肝纤维化大鼠模型LN、COL₄、HA的影响 (n = 8)

分组	LN	COL4	HA
Contrl	659.4 ± 87.34	314.8 ± 24.21	10.2 ± 0.79
Model	1021.6 ± 68.75a	400.8 ± 58.07a	13.8 ± 1.36a
Silybin	587.8 ± 44.10e	420.0 ± 31.40	11.0 ± 1.77
HTL	778.1 ± 123.46d	328.9 ± 53.50	12.8 ± 0.65
HTM	817.9 ± 93.64c	312.3 ± 63.74c	12.7 ± 1.78
HTH	630.1 ± 50.82e	353.3 ± 47.93	12.4 ± 1.75
HXHYL	818.7 ± 61.19c	282.0 ± 27.33e	13.2 ± 2.22
HXHYM	887.6 ± 94.67	348.7 ± 47.40	11.6 ± 1.01c
HXHYH	754.4 ± 114.4d	350.1 ± 57.72	11.7 ± 1.08
FZL	837.0 ± 103.79c	336.0 ± 42.03	11.7 ± 1.51c
FZM	838.2 ± 142.65	314.3 ± 59.28c	12.0 ± 1.11
FZH	695.7 ± 70.64e	344.6 ± 50.74	11.6 ± 1.07
HTHXFZL	801.3 ± 123.81c	274.4 ± 47.09e	12.2 ± 1.42
HTHXFZ	502.4 ± 122.0e	246.9 ± 22.2e	12.4 ± 1.05
M	720.6 ± 136.14e	252.9 ± 30.8e	11.4 ± 0.89d
HTHXFZH

^aP<0.05与正常组比较;

^cP<0.05,

^dP<0.01,

^eP<0.001与模型组比较. LN: 层黏连蛋白; COL₄: Ⅳ型胶原蛋白; HA: 透明质酸酶.