临床研究
Copyright ©The Author(s) 2011.
世界华人消化杂志. 2011-07-08; 19(19): 2022-2030
在线出版 2011-07-08. doi: 10.11569/wcjd.v19.i19.2022
表1 HIF-1α、Snail、Slug、E-cadherin、E-cadherin蛋白在PDAC和正常胰腺组织中的表达
蛋白评级(n)
阳性率(%)
-++++++
HIF-1α
PDAC2822311169.57
对照组001010.00
Snail
PDAC281445569.57
对照组00000.00
Slug
PDAC386361258.70
对照组00000.00
E-cadherin
PDAC581217536.96
对照组124390.00
N-cadherin
PDAC241844673.91
对照组00000.00
表2 PDAC中HIF-1α与Snail、Slug表达的关系
nHIF-1α
rP
-++++++
Snail
-281161100.3090.005
+141823
++45148185
+++52003
n28223111
Slug
-381851230.2310.027
+60330
++36712143
+++123225
n28223111
表3 PDAC中Snail与E-cadherin表达的关系
E-cadherinnSnail
rP
-++++++
-581312303-0.2230.033
+123090
++178252
+++54010
n2814455
表4 PDAC中Slug与E-cadherin表达的关系
E-cadherinnSlug
rP
-++++++
-58225308-0.1370.194
+121792
++172352
+++51110
n3863612
表5 PDAC中E-cadherin与N-cadherin表达的关系
N-cadherinnE-cadherin
rP
-++++++
-2472114-0.4780.000
+1811241
++4436620
+++64200
n5812175
表6 HIF-1α、Snail、Slug、E-cadherin、N-cadherin蛋白的表达与PDAC临床病理特征的关系
参数nHIF-1α
Snail
Slug
E-cadherin
N-cadherin
PPP阴性阳性PP
TNM分期
211560.0858130.0311650.0031290.7181740.000
Ⅱa3721162314191825121720
Ⅱb, Ⅲ, Ⅳ341420112310242113826
淋巴结转移
阴性5736210.03030270.08635220.00236210.97734230.001
阳性351421122310252213827
分化
G1141040.336860.349770290860.857950.010
G26030302832322839212931
G31688511511106214
表7 92例PDAC患者的生存分析
参数单因素P多因素
PRR95%CI
年龄(≤60岁vs >60岁)0.796
性别(男vs女)0.217
部位(头部vs体尾部)0.194
大小(≤2 cm vs >2 cm)0.203
TNM分期(Ⅰa/Ⅰb/Ⅱa/Ⅱb/Ⅲ/Ⅳ)0.0300.0011.5451.206-1.978
淋巴结(阴性vs阳性)0.0160.433
切缘(阴性vs阳性)0.0290.733
神经(阴性vs阳性)0.902
分化(G1/G2/G3)0.167
HIF-1α(高表达vs低表达)0.0000.0012.6781.500-4.781
Snail(高表达vs低表达)0.0030.0022.5531.411-4.616
Slug(高表达vs低表达)0.0310.455
E-cadherin(阳性vs阴性)0.0010.0010.3270.173-0.618
N-cadherin(高表达vs低表达)0.0000.370

引文著录: 朱光辉, 岑刚, 黄陈, 张志华, 冯正中, 吕秀红, 裘正军. HIF-1α和EMT相关蛋白在胰腺癌组织中的表达及临床意义. 世界华人消化杂志 2011; 19(19): 2022-2030