应用SELDI-TOF-MS技术分析SEB染毒小鼠血清蛋白质组学变化

表1 SEB中毒小鼠血清中的差异蛋白质

质/荷(m/z)	P值	↑↓
1054.37	0.016	↑
1626.13	0.025	↑
5617.20	0.004	↓
6031.67	0.025	↓
8330.56	0.025	↓
14 423.36	0.016	↑
14 788.10	0.016	↑
21 931.03	0.025	↑
31 407.82	0.025	↑
44 806.19	0.025	↑
45 470.37	0.037	↑

表2 SWISS-PROT蛋白质数据库分析

理论Mr	在SWISS-PROT小鼠蛋白质数据库中的检索结果
1054.37	Angiotensinogen
5617.20	TGF-α
6031.67	Granulins(PC cell-derived growth factor)
8330.56	Cytochrome C oxidase polypeptide Vic, Small inducible cytokine B5
14423.36	Cystatin F, Leptin receptor overlapping transcript-like1, Profilin, Ribonuclease K6
14788.49	Bone morphogenetic protein 6(BMP-6)(VGR-1), Fatty acid-binding protein, Ribulose bisphosphate carboxylase small chain 1B
21931.01	α-1-acid glycoprotein 1, SERTA domain-containing protein3, Tumor necrosis factor ligand superfamily member 7, Uracil phosphoribosyltransferase
31407.82	Killer cell lectin-like receptor 8, Ras suppressor protein 1, Erythrocyte band 7 integral membrane protein
44806.19	Aspartate a minotransferase, 47kDa heat shock protein, LAG1 longevity assurance homolog 6, Phosphorylase b kinase gamma catalytic chain, 3-ketoacyl-CoA thiolase 2
45470.37	Synaptotag min7, Transcription factor 7(T-cell-specific transcription factor1), TNF receptor-associated factor 1