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Effect of Xiangsha Pingweisan on gastric emptying motility in mice
Xue-Qing Wang, Xiu-Jie Wang, Yan Li
Xue-Qing Wang, Yan Li, Department of Digestive Diseases, Second Affiliated Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Xiu-Jie Wang, Department of Digestive Diseases, Fifth Hospital of Shenyang City, Shenyang 110023, Liaoning Province, China
Correspondence to: Xue-Qing Wang, Department of Digestive Diseases, Second Affiliated Hospital, China Medical University, Shenyang 110004, Liaoning Province, China.
Received: October 7, 2002 Revised: October 10, 2002 Accepted: October 18, 2002 Published online: May 15, 2003
To evaluate the effects of Chinese herbs Xiangsha Pingweisan (XSPWS) decoction and its component on gastric emptying in healthy mice.
Mice were randomly divided into control group, cisapride group and XSPWS group. The effects of XSPWS on gastric emptying were investigated in vivo by measuring gastric remainder rates of Blue Dextron (BD) 2000. Additionally, the effect of each component herb in XSPWS recipe was evaluated in the same way according to orthogonal design.
Compared with control group [(100.0±24.2)%], the rates of gastric remainder in XSPWS group [(39.5±18.3)%] and cisapride group [(36.9±16.4)%] were all significantly decreased (P < 0.05). There were no significant difference between XSPWS group and cisapride group (P > 0.05). Except radix glycyrrhizae preparta group, the gastric emptying rates of other component herbal groups were significantly higher than that of control group (P < 0.01). Based on the analysis of orthogonal design, there were wide杛anging first杇rade mutual roles within the six component herbs.
XSPWS and its some component herbs can accelerate the gastric emptying in mice in vito significantly. There are wide-Ranging first-Grade mutual roles within the six component herbs.
Key Words: N/A
Citation: Wang XQ, Wang XJ, Li Y. Effect of Xiangsha Pingweisan on gastric emptying motility in mice. Shijie Huaren Xiaohua Zazhi 2003; 11(5): 571-574
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