Prognostic value of early changes in artificial intelligence-based computed tomography-measured body composition in pediatric osteosarcoma receiving neoadjuvant chemotherapy

doi:10.35713/aic.v7.i1.116464

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Artificial Intelligence in Cancer

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2644-3228

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

Artif Intell Cancer. Sep 8, 2026; 7(1): 116464
Published online Sep 8, 2026. doi: 10.35713/aic.v7.i1.116464

Table 4 Kaplan-Meier analysis for the association between independent predictors and overall survival

Variable	Cut-off point	Group	Median survival time (95%CI)	Log rank test
Pre-chemotherapy SMI	48.86 cm²/m²	Low	88.297 (77.206-99.388)	0.066
Pre-chemotherapy SMI	48.86 cm²/m²	High	64.739 (43.620-85.858)	0.066
Pre-chemotherapy PNI	50.25	Low	72.654 (57.202-88.107)	0.002
Pre-chemotherapy PNI	50.25	High	82.702 (73.927-91.478)	0.002
Post-chemotherapy ALP	380 g/L	Low	89.401 (78.820-99.981)	0.012
Post-chemotherapy ALP	380 g/L	High	44.397 (28.647-60.148)	0.012
ΔSMD	6.27 HU/30 days	Low	94.657 (86.277-103.037)	0.001
ΔSMD	6.27 HU/30 days	High	43.356 (29.130-57.581)	0.001
Integrated index	-1.09	Low	94.319 (85.826-102.813)	0.010
Integrated index	-1.09	High	46.988 (33.710-60.267)	0.010

Δ: Body compartment area change per 30 days. CI: Confidence interval; SMI: Skeletal muscle index; PNI: Prognostic nutritional index; ALP: Alkaline phosphatase; SMD: Skeletal muscle density; HU: Hounsfield unit.

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Citation: Yang YH, Li Y. Prognostic value of early changes in artificial intelligence-based computed tomography-measured body composition in pediatric osteosarcoma receiving neoadjuvant chemotherapy. Artif Intell Cancer 2026; 7(1): 116464
URL: https://www.wjgnet.com/2644-3228/full/v7/i1/116464.htm
DOI: https://dx.doi.org/10.35713/aic.v7.i1.116464

Yang YH, Li Y. Prognostic value of early changes in artificial intelligence-based computed tomography-measured body composition in pediatric osteosarcoma receiving neoadjuvant chemotherapy. Artif Intell Cancer 2026; 7(1): 116464 [DOI: 10.35713/aic.v7.i1.116464]

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