Prognostic value of early changes in artificial intelligence-based computed tomography-measured body composition in pediatric osteosarcoma receiving neoadjuvant chemotherapy

Table 2 Results of multivariant logistic regression analysis for the association between changes in body compartment measurements and histopathological response to neoadjuvant chemotherapy

Variable	P value1	Coefficient2	SE	Wald χ2	HR	95%CI
Age, years	0.031	0.254	0.118	4.640	1.289	1.023-1.625
Maxium tumor length, cm	0.067	0.073	0.040	3.352	1.075	0.995-1.162
Post-chemotherapy SII	0.032	-0.001	0.000	4.590	0.999	0.999-1.000
ΔSMD, HU/30 days	0.017	0.153	0.064	5.726	1.165	1.028-1.321
Constant	0.002	-5.993	1.939	9.558	0.002	-

¹Based on likelihood test adjusted for the other factors in the final mode.

²Estimated coefficient for the variable and the associated standard error.

Δ: Body compartment area change per 30 days; HR: Hazard ratio; CI: Confidence interval; SII: Systemic immune-inflammation index; SMD: Skeletal muscle density; HU: Hounsfield unit.