Neutrophil gelatinase-associated lipocalin does not predict acute kidney injury in heart failure

Table 1 Patient characteristics stratified by cardiorenal syndrome type 1 diagnosis

Patient charateristics	All patients (n = 202)	No-CRS-1 patients (n = 147) (72.8%)	CRS-1 patients (n = 55) (27.2%)	P value
Age (yr)	67 (57-77)	64 (65-72)	77 (67-83)	< 0.001
Gender: Male/female	142/60	106/40	36/20	0.30
Creatinine admission (μmol/L)	78.3 (66.9-97.7)	72.2 (65.1-82.7)	124.1 (102-174.2)	< 0.001
Creatinine peak (μmol/L)	87.1 (72.2-117)	77.4 (70.4-89.8)	142.6 (121.4-1.98)	< 0.001
BUN at admission (μmol/L)	13.2 (10.3-17.8)	12.1 (10-14.2)	21.4 (16-25.7)	< 0.001
Urine output by 24 h (mL)	1585 (900-2625)	1700 (1100-2650)	1200 (700-2300)	0.0034
Furosemide use ≥ 120 mg/24 h	79 (39.70)	63 (43.45)	16 (29.63)	0.20
ΔNGAL (ng/dL)	-8 [(-29)-17]	-6 [(-24)-17]	-13 [(-112)-20]	0.14
NGAL peak (ng/dL)	147 (81-245.5)	153.5 (80-256)	121 (86-188)	0.31
NGAL cut-off (≥ 140 ng/mL)	102 (50.50)	79 (48.30)	23 (41.82)	0.20
Troponin I peak (μg/L)	4.72 (0.36-34.51)	2.21 (0.25-25.26)	10.67 (1.52-47.76)	0.02
NTproBNP peak (pg/mL)	200 (93.60-559.0)	203.5 (104.5-570.5)	180.5 (89.0-475.0)	0.68
K (mmol/L)	3.9 (3.7-4.2)	3.9 (3.7-4.1)	4.2 (3.8-4.5)	< 0.001
Hb (g/L)	132 (121-143)	134 (126-145)	120 (105-133)	< 0.001
Systolic arterial pressure (mmHg)	135 (120-151)	139 (120-151)	135 (110-150)	0.18
Dyastolic arterial pressure (mmHg)	70 (60-80)	70 (65-80)	65 (55-75)	0.01
Mean arterial pressure (mmHg)	92 (82-107)	94 (86-105)	89 (75-100)	0.04
EF ≤ 40%	44 (32.35)	34 (34.69)	10 (26.32)	0.35
Severe dilation left ventriculus1, n (%)	22 (11.06)	15 (10.34)	7 (12.96)	0.82
Catecolamine use, n (%)	10 (4.95)	7 (4.76)	3 (5.45)	0.8
IABP use, n (%)	12 (5.94)	6 (4.08)	6 (12.76)	0.07
CICU mortality, n (%)	6 (3)	3 (2)	3 (5)	0.3

¹Dilation of the left ventriculus (see Ref. 15). CICU: Cardiac intensive care unit; EF: Ejection fraction; IABP: Intra-aortic balloon pump; CRS-1: Cardiorenal syndrome type 1; NGAL: Neutrophil gelatinase-associated lipocalin; BUN: Blood urea nitrogen.

Table 2 Multivariable logistic regression models for prediction of cardiorenal syndrome type 1

	OR	P value	95%CI
Age > 60 yr	5.21	0.003	1.74-15.54
BUN at admission	1.06	0.000	1.03-1.08
Diuresis by 24 h	1.01	0.027	1.00-1.03

OR: Odd ratio; CI: Confidence interval; BUN: Blood urea nitrogen.