Bleeding and clotting in hereditary hemorrhagic telangiectasia

Table 1 The Curacao criteria for the diagnosis of hereditary hemorrhagic telangiectasia

Criteria	Description	Percent manifestation
1 Epistaxis	Spontaneous, recurrent	90
2 Telangiectases	Multiple, at characteristic sites:	80
	Lips
	Oral cavity
	Finger tips
	Nose
3 Visceral lesions	Gastrointestinal telangiectasia	15-30
	Pulmonary AVMs	50
	Hepatic AVMs	30-70
	Cerebral AVMs	10-20
	Spinal AVMs	< 1
4 Family history	Affected first degree relative
Diagnosis of HHT:
Definite: 3-4 criteria	Possible: 2 criteria	Unlikely: 0-1 criterion

HHT: Hereditary hemorrhagic telangiectasia; AVMs: Arteriovenous malformations.