Elevated soluble 4-1BB is associated with serum markers of hepatitis B virus in patients with chronic hepatitis B

Table 2 Correlation between clinical features and the level of soluble 4-1BB

	s4-1BB
	r	P value
HBsAg in IU/mL	0.748	< 0.001
HBV DNA as log10 IU/mL	0.406	0.004
HBeAg in s/co	0.356	0.019
ALT in U/L	0.234	0.102
AST in U/L	0.165	0.246
GGT in U/L	0.076	0.595
ALP in U/L	-0.065	0.651
TBIL in µmol/L	0.063	0.662
BUN in mmol/L	-0.075	0.623
SCr in µmol/L	-0.226	0.135
WBC as × 109/L	-0.171	0.229
HGB in g/L	-0.063	0.662
PLT as × 109/L	-0.150	0.293
INR	0.344	0.014
PTA, %	-0.353	0.012
FBG in mmol/L	-0.002	0.988
TC in mmol/L	-0.350	0.050
TG in mmol/L	-0.469	0.007
HDL in mmol/L	0.148	0.481
LDL in mmol/L	-0.360	0.077
IFNα in pg/mL	-0.282	0.146
IFNγ in pg/mL	-0.314	0.104
IL-12 in pg/mL	-0.076	0.702
IP-10 in pg/mL	0.154	0.434
TNFα in pg/mL	-0.031	0.874

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; BUN: Blood urea nitrogen; FBG: Fasting blood glucose; GGT: γ-Glutamyl transpeptidase; HBeAg: Hepatitis B e antigen; HBsAg: Hepatitis B surface antigen; HBV: Hepatitis B virus; HDL: High-density lipoprotein; HGB: Hemoglobin; INR: International normalized ratio; LDL: Low-density lipoprotein; PLT: Platelet; PTA: Plasma thromboplastin antecedent; s4-1BB: Soluble 4-1BB; SCr: Serum creatinine; TBIL: Total bilirubin; TC: Total cholesterol; TG: Triglyceride; WBC: White blood cell.