Construction of a clinical survival prognostic model for middle-aged and elderly patients with stage III rectal adenocarcinoma

Table 3 Multivariate Cox regression analysis.

Variable	OS			CSS
	HR	95%CI	P value	HR	95%CI	P value
Age (yr)
45-62
62-75	1.773	1.384-2.272	< 0.001	1.731	1.311-2.286	< 0.001
> 75	3.427	2.601-4.516	< 0.001	2.976	2.157-4.106	< 0.001
Grade
I/II
III/IV	1.188	0.914-1.545	0.198	1.281	0.96-1.709	0.092
Stage
III A
III B	1.680	1.005-2.809	0.047	2.369	1.204-4.662	0.013
III C	1.770	0.968-3.24	0.064	2.960	1.391-6.297	0.005
Tumor size
≤ 68
> 68	1.669	1.277-2.18	< 0.001	1.638	1.209-2.219	0.001
CEA
Low
High	1.426	1.148-1.772	0.001	1.261	0.986-1.612	0.064
TD
Neg
Pos	1.525	1.204-1.933	< 0.001	1.520	1.164-1.985	0.002
CRM
Neg
Pos	1.538	1.204-1.963	< 0.001	1.773	1.351-2.328	< 0.001
PNI
Neg
Pos	1.550	1.204-1.996	< 0.001	1.520	1.147-2.015	0.004
pLN
0
1-6	1.096	0.784-1.532	0.592	1.378	0.925-2.053	0.115
> 6	0.895	0.497-1.612	0.712	1.076	0.57-2.031	0.821
DLNs
≤ 26
> 26	1.254	0.928-1.694	0.141
LNR
0-0.12
< 0.31	1.279	0.953-1.717	0.101	1.330	0.963-1.839	0.084
> 0.31	1.871	1.298-2.697	< 0.001	1.809	1.22-2.684	0.003

OS: Overall survival; CCS: Cancer-specific survival; HR: Hazard ratios; CEA: Carcinoembryonic antigen; TD: Tumor engraftment; CRM: Circumferential resection margin; PNI: Perineural invasion; pLN: Positive lymph nodes; DLNs: Examined lymph nodes; LNR: Lymph node-positive rate.