Construction of a clinical survival prognostic model for middle-aged and elderly patients with stage III rectal adenocarcinoma

Table 2 Univariate Cox regression analysis

Variable	OS			CSS
	HR	95%CI	P value	HR	95%CI	P value
Age (yr)			< 0.001			< 0.001
45-62
62-75	1.684	1.32-2.148	< 0.001	1.649	1.649-1.255	< 0.001
> 75	3.102	2.372-4.057	< 0.001	2.687	2.687-1.964	< 0.001
Race			0.3			0.4
Other
White	0.752	0.519-1.091	0.134	0.7399	0.739-0.485	0.163
Black	0.682	0.432-1.076	0.009	0.7474	0.747-0.449	0.262
Sex			0.08			0.3
Female
Male	1.209	0.9731-1.502	0.087	1.139	1.139-0.8914	0.297
Grade			< 0.001			< 0.001
I/II
III/IV	1.214	2.02-1.214	< 0.001	1.788	1.788-1.352	< 0.001
Site			0.3			0.4
Rectosigmoid Junction
Rectum	0.894	0.718-1.114	0.319	0.889	0.889-0.693	0.356
Stage			< 0.001			< 0.001
III A
III B	2.399	1.446-3.979	< 0.001	3.225	3.225-1.651	< 0.001
III C	3.941	2.316-6.706	< 0.001	6.037	6.037-3.027	< 0.001
Tumor size size			< 0.001			< 0.001
≤ 68
> 68	1.651	1.279-2.131	< 0.001	1.663	1.663-1.245	< 0.001
CEA			< 0.001			< 0.001
Low
High	1.724	1.395-2.131	< 0.001	1.576	1.576-1.239	< 0.001
TD			< 0.001			< 0.001
Neg
Pos	2.009	1.612-2.504	< 0.001	2.072	2.072-1.614	< 0.001
CRM			< 0.001			< 0.001
Neg
Pos	2.205	1.756-2.77	< 0.001	2.551	2.551-1.981	< 0.001
PNI			< 0.001			< 0.001
Neg
Pos	2.092	1.665-2.629	< 0.001	2.222	2.222-1.718	<0.001
pLN			< 0.001			<0.001
0
1-6	1.379	1.039-1.831	0.026	1.711	1.711-1.21	0.002
> 6	2.27	1.594-3.233	< 0.001	2.924	2.924-1.927	< 0.001
DLNs			0.02			0.07
≤ 26
> 26	1.412	1.072-1.858	0.014	1.348	1.348-0.981	0.066
LNR			< 0.001			< 0.001
0-0.12
< 0.31	1.405	1.088-1.815	0.009	1.64	1.64-1.228	< 0.001
> 0.31	2.261	1.755-2.914	< 0.001	2.594	2.594-1.944	< 0.001

OS: Overall survival; CCS: Cancer-specific survival; HR: Hazard ratios; CEA: Carcinoembryonic antigen; TD: Tumor engraftment; CRM: Circumferential resection margin; PNI: Perineural invasion; pLN: Positive lymph nodes; DLNs: Examined lymph nodes; LNR: Lymph node-positive rate.