Severe digital ischemia coexists with thrombocytopenia in malignancy-associated antiphospholipid syndrome: A case report and review of literature

Table 2 Summary of reported paraneoplastic syndromes of hepatocellular carcinoma

Category	Associated diseases/condition	Ref.
Hematologic syndromes	Severe eosinophilia	Yuen et al[23], 1995
	Hemophagocytic syndrome	Sakai et al[24], 2001
	Erythrocytosis	Tsuchiya et al[25], 2009
	Leukemoid reaction	Shin et al[26], 2011
	Thrombocytosis	Abbas et al[27], 2019
Rheumatologic syndromes	Raynaud's phenomenon	Sahan et al[6], 2006
	Polymyositis	Thanapirom et al[28], 2014
	Dermatomyositis	Chou et al[7], 2017
	Polyarthritis	Sathiyapalan et al[29], 2021
Dermatologic syndromes	Symptomatic porphyria	Ochiai et al[30], 1997
	Disseminated superficial porokeratosis	Kono et al[31], 2000
	Cutaneous lupus erythematosus	Ho et al[32], 2001
	Erythema nodosum	Glinkov et al[33], 2003
	Pemphigus	Yokokura et al[34], 2006
	Generalized granuloma annulare	Cho et al[35], 2018
Endocrine syndromes	Hypercholinesterasemia	Tajiri et al[36], 1983
	Hyperlipidemia	Makino et al[37], 1986
	Hyperestrogenia	Salles et al[38], 1987
	Hyperthyroidism	Carri et al[39], 1989
	Hyperthyroxinemia	Nizam et al[40], 1995
	Carcinoid syndrome	Nwokediuko et al[41], 2010
	Hypercalcemia	Newman et al[5], 2015
	Hyperglycemia	Kim et al[42], 2015
Neurologic or neuropsychiatric syndromes	Necrotizing myelopathy	Misumi et al[43], 1988
	Neurologic manifestations	Norris et al[44], 1997
	Demyelinating polyneuropathy	Walcher et al[45], 2002
	Peripheral neuropathy	Matsui et al[46], 2015
	Neuropsychiatric manifestations	Karam et al[47], 2020
	Hyperammonemic encephalopathy	Lee et al[48], 2021
Miscellaneous syndromes	Hypertension	Arai et al[4], 1999
	Membranous glomerulonephritis	Texier et al[49], 2004
	Nummular loss of the retinal pigment epithelium	Lee et al[50], 2007
	Myasthenia gravis	Vautravers et al[51], 2008
	Rhabdomyolysis	Bárdos et al[52], 2021