Nomogram based on inflammation-related markers for predicting survival of patients undergoing hepatectomy for hepatocellular carcinoma

Table 2 Univariate and multivariate Cox regression analyses in the training cohort

	Univariate Model				Multivariate Model
	HR	95%CI		P value	HR	95%CI		P value
Age, yr
< 50	Ref.
≥ 50	0.837	0.642	1.090	0.187
Sex
Male	Ref.
Female	1.065	0.809	1.401	0.655
Smoking
No	Ref.
Yes	0.959	0.748	1.230	0.741
Drinking
No	Ref.
Yes	0.986	0.787	1.234	0.900
ALBI Grade
1	Ref.
2 and 3	1.032	0.821	1.290	0.820
HBsAg
Negative	Ref.
Positive	1.063	0.833	1.365	0.639
Tumour location
Left	Ref.
Right	1.263	0.942	1.693	0.119
Others	1.359	0.855	2.159	0.195
Tumour size, cm
< 5	Ref.
≥ 5	1.595	1.255	2.027	< 0.001	1.323	1.002	1.747	0.048
Grade
Well differentiated	Ref.				Ref.
Moderately differentiated	1.421	1.031	1.959	0.032	1.752	1.246	2.463	0.001
Poorly differentiated	1.669	1.047	2.661	0.031	3.207	1.944	5.290	< 0.001
MVI
No	Ref.
Yes	1.171	0.905	1.515	0.230
AFP, μg/L
< 400	Ref.
≥ 400	1.757	1.347	2.293	< 0.001	1.812	1.343	2.444	< 0.001
NLR
Low	Ref.
High	2.744	2.152	3.498	< 0.001	2.480	1.856	3.312	< 0.001
PLR
Low	Ref.
High	2.212	1.748	2.800	< 0.001	1.974	1.490	2.616	< 0.001

ALBI: Albumin–bilirubin; CI: Confidence interval; HBsAg: Hepatitis B surface antigen; HR: Hazard ratio; MVI: Microvascular invasion; AFP: α-fetoprotein; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio.