Clinical significance of signet ring cells in surgical esophageal and esophagogastric junction adenocarcinoma: A systematic review and meta-analysis

Table 1 Basic characteristics of included studies

Author	Year	Country	Sample size	Location	TNM	SRC ratio	Endpoint	NOS
Chirieac et al[11]	2005	United States (ACC: 1985-2003)	193	Esophageal + EGJ	I-IV	> 0%	OS	7
Chirieac et al[11]	2005	United States (ACC: 1985-2003)	219	Esophageal + EGJ	I-IV	> 0%	OS	7
Yoon et al[12]	2010	United States (MCTR)	796	Esophageal + EGJ	NR	> 0%	OS, DSS, DFS	6
Yendamuri et al[13]	2013	United States (SEER)	11825	Esophageal	I-IV	> 0%	OS,	7
Nafteux et al[14]	2014	Belgium	779	Esophageal + EGJ	I-IV	1%-50%, > 50%	DSS	7
Patel et al[15]	2014	United States (ACC: 2000-2012)	723	Esophageal + EGJ	II-IV	> 0%	OS, DFS	7
Chen et al [16]	2017	China	671	Esophageal	I-III	1%-50%, > 50%	OS	8
Van Hootegem et al[17]	2019	Australia	298	Esophageal + EGJ	NR	> 0%	OS, DFS	7
Van Hootegem et al[17]	2019	Australia	391	Esophageal + EGJ	NR	> 0%	OS, DFS	7
Corsini et al[18]	2020	United States (ACC: 2006-2018)	819	Esophageal	NR	1%-10%, 11%-49%, ≥ 50%	OS	8
Sathe et al[19]	2020	United States (NCD: 2004-2015)	14224	Esophageal + EGJ	I-III	NR	OS	7
Solomon et al[20]	2021	Israel	163	Esophageal + EGJ	I-III	> 0%	OS	6

SRC: Signet ring cell; NOS: Newcastle-Ottawa Scale; EGJ: Esophagogastric junction; Surg: Surgery; nCT: Neoadjuvant chemotherapy; OS: Overall survival; DSS: Disease-specific survival; DFS: Disease-free survival; SEER: Surveillance, Epidemiology, and End Results; R: Recurrence; ACC: Anderson Cancer Center; MCTR: Mayo Clinic Tumor Registry; RTCT: Response to chemotherapy; NCD: National Cancer Database; DS: Downstaging; TNM: Tumor-node-metastasis; NR: Not reported.