Regulating monocyte infiltration and differentiation: Providing new therapies for colorectal cancer patients with COVID-19

Figure 1 Severe acute respiratory syndrome coronavirus 2 recognition proteins are highly expressed in the tumor tissues of patients with colorectal cancer. A: In the TCGA and GTEx databases, expression of angiotensin I converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) was significantly higher in in colorectal cancer (CRC) tumors than in healthy tissues (P < 0.01); B: single-cell sequencing analysis of 27,414 cells from six CRC patients found that ACE2 and TMPRSS2 expression was higher in CRC than in healthy tissue, and was mainly expressed in epithelial cells; C: Expression of ACE2, TMRPSS2, cathepsin B, and cathepsin L was higher in CRC than in normal tissue in both stromal and epithelial cells analysis of single-cell sequencing (Gene Expression Omnibus: GSE144735). ACE2: Angiotensin I converting enzyme 2; CRC: Colorectal cancer; CTSB: Cathepsin B; CTSL: Cathepsin L; GTEx: Genotype-tissue expression; TCGA: The Cancer Genome Atlas; TMPRSS2: Transmembrane serine protease 2; UMAP: Uniform manifold approximation and projection.