Endoscopic ultrasound fine needle aspiration vs fine needle biopsy in solid lesions: A multi-center analysis

Table 3 Comparison between methods with and without rapid on-site evaluation

	FNA alone	FNA with ROSE	FNB alone	FNB with ROSE
Sensitivity	63.19% (95%CI 55.29 to 70.60)	86.45% (95%CI 80.04 to 91.41)	81.66% (95%CI 77.50 to 85.34)	82.97% (95%CI 76.70 to 88.12)
Specificity	96.69% (95%CI 91.75 to 99.06)	100.00% (95%CI 86.77 to 100.00)	100.00% (95%CI 95.04 to 100.00)	100.00% (95%CI 75.29 to 100.00)
Positive likelihood ratio	19.12 (95%CI 7.24 to 50.46)	NA	89.82 (95%CI 12.76 to 632.37)	NA
Negative likelihood ratio	0.38 (95%CI 0.31 to 0.47)	0.14 (95%CI 0.09 to 0.20)	0.19 (95%CI 0.15 to 0.23)	0.17 (95%CI 0.12 to 0.23)
Positive predictive value	96.26% (95%CI 90.70 to 98.55)	100.00%	99.69% (95%CI 97.88 to 99.96)	100.00%
Negative predictive value	66.10% (95%CI 61.40 to 70.51)	55.32% (95%CI 45.41 to 64.82)	59.89% (95%CI 54.81 to 64.77)	29.55% (95%CI 23.33 to 36.62)
Accuracy	77.46% (95%CI 72.16 to 82.19)	88.40% (95%CI 82.81 to 92.67)	85.43% (95%CI, 82.06 to 88.39)	84.10% (95%CI 78.20 to 88.94)

FNA: Fine needle aspiration; FNB: Fine needle biopsy; ROSE: Rapid on-site evaluation.