Endoscopic ultrasound fine needle aspiration vs fine needle biopsy in solid lesions: A multi-center analysis

Table 1 Baseline patient characteristics, lesion details, and sampling characteristics

Results	Total	FNA	FNB	P value
Patient characteristics
No. of patients	1168	468 (40.07)	700 (59.93)
Age (yr)	65.02 (12.29)	64.24 (11.59)	65.54 (12.72)	0.078
Gender				0.098
No. of males (%)	652 (55.82)	275 (58.76)	377 (52.86)
No. of females (%)	516 (44.18)	193 (41.24)	323 (47.14)
Lesion site
Pancreatic	574 (49.14)	194 (41.45)	380 (54.29)	< 0.001
Non-pancreatic
Lymph node	209 (17.89)	108 (23.08)	101 (14.43)	< 0.001
Subepithelial	229 (19.61)	115 (24.57)	114 (16.28)	< 0.001
Other solid lesions	156 (13.36)	51 (10.90)	105 (15.00)	< 0.001
Hepatic mass	48 (4.11)	18 (37.50)	30 (62.50)
Abdominal mass	29 (2.48)	8 (27.59)	21 (72.41)
Gastrointestinal wall thickening	20 (1.71)	6 (0.30)	14 (0.70)
Mediastinal mass	14 (0.43)	4 (28.57)	10 (71.43)
Peri-rectal mass	11 (0.94)	3 (27.37)	8 (72.73)
Common bile duct mass	9 (0.77)	5 (55.56)	4 (44.44)
Duodenal mass	6 (0.51)	1 (16.67)	5 (83.33)
Ampullary mass	6 (0.51)	1 (16.67)	5 (83.33)
Retroperitoneal mass	5 (0.43)	1 (20.00)	4 (80.00)
Esophageal mass	3 (0.26)	0 (0.00)	3 (100.00)
Gallbladder mass	3 (0.26)	2 (66.67)	1 (33.33)
Splenic mass	2 (0.17)	2 (100.00)	0 (0.00)
Lesion size (mm)	24.16 (13.63)	22.10 (13.34)	25.52 (13.65)	< 0.001
Diagnostic sample approach				0.007
Transesophageal	124 (11.02)	63 (50.81)	61 (49.19)
Transgastric	589 (52.36)	235 (39.90)	354 (60.10)
Tranduodenal	388 (34.49)	135 (34.79)	253 (65.21)
Transrectal	21 (1.87)	11 (52.38)	10 (47.62)
Other	3 (0.26)	0 (0.00)	3 (100.00)
Needle size				< 0.001
19G	8 (0.69)	2 (0.43)	6 (0.86)
20G	7 (0.61)	0 (0.00)	7 (1.00)
21G	8 (0.69)	0 (0.00)	8 (1.15)
22G	644 (55.61)	216 (46.55)	428 (61.49)
25G	491 (42.40)	246 (53.02)	245 (35.20)
No. of passes	2.89 (1.51)	2.91 (1.61)	2.88 (1.45)	0.701
No. of samples with ROSE				< 0.001
Yes	377 (32.28)	182 (38.89)	195 (27.86)
No	791 (67.72)	286 (61.11)	505 (72.14)
Adequate sample for ROSE				0.474
Yes	291 (77.19)	136 (74.73)	155 (79.49)
No	86 (22.81)	46 (25.27)	40 (20.51)
No. of passes for ROSE adequacy	3.37 (1.73)	3.32 (1.74)	3.41 (1.73)	0.664
No. of samples with cell block				< 0.001
Yes	1014 (86.82)	366 (78.21)	648 (92.57)
No	154 (13.18)	102 (21.79)	52 (7.43)
No. of passes for cell block diagnosis	2.97 (1.54)	3.09 (1.67)	2.90 (1.46)	0.067

ROSE: Rapid on-site evaluation; FNA: Fine needle aspiration; FNB: Fine needle biopsy.