Role of circular RNAs in gastrointestinal tumors and drug resistance

Table 2 circRNAs involved in liver cancer gene transcription regulation and drug resistance

Cancer type	circRNA	Gene expression		Mechanism	Drug	Ref.
		Up	Down
Liver cancer	circ100084	↑		Promotes IGF2 expression by acting as a sponge for HSA-MIR-23A-5P	NR	[81]
Liver cancer	circABCB10	↑		Upregulates HMG20A expression by acting as a miR-670-3p sponge	NR	[83]
Liver cancer	circRNA-101237	↑		Increased levels in serum and Huh7 cells of cisplatin-resistant HCC patients	Cisplatin	[84]
Liver cancer	Hsa-circ-u0006294, hsa-circ-u0035944, hsa-circ-u0084663		↓	Plays a role by activating the Wnt/β-catenin pathway	Sorafenib	[85]
Liver cancer	circ-0003418		↓	Inhibits Wnt/β-catenin pathway	Cisplatin	[86]
Liver cancer	circFBXO11	↑		Uses miR-605 /FOXO3/ABCB1 axis adjustment	Oxaliplatin	[87]

NR: Not reported; circRNA: Circular RNA.