Utility of cooling patches to prevent hand-foot syndrome caused by pegylated liposomal doxorubicin in breast cancer patients

Table 1 Clinical characteristics of the study population at baseline

	Control group	Cooling group	F	Z	P value
Age	51.18 ± 9.27 yr	51.24 ± 10.16 yr	0.863		0.977
Weight	64.20 ± 10.29 kg	65.37 ± 9.74 kg	0.404		0.558
BMI	24.50 ± 3.60 kg/m2	24.98 ± 3.66 kg/m2	0.042		0.503
Height	162 (158-165) cm	162 (160-165) cm		-0.044	0.965
Body surface area	1.6975 (1.6005-1.799) m2	1.723 (1.646-1.802) m2		-0.802	0.423
PLD dose	60 (54.25-60) mg	60 (60-60) mg		-1.53	0.126
Total PLD dose	240 (220-240) mg	240 (240-240) mg		-1.04	0.299
Chemotherapy cycle	4 cycles, 21 d/cycle
Leukocytes	5.66 (4.48-7.0875)	6.02 (4.92-7.47)		-0.971	0.331
Platelets	249.5 (225.5-301.25)	233 (203-270)		-1.96	0.05
Albumin	47.59 (43.375-49.025)	46.5 (44.8-48.424)		-0.194	0.846
Alanine aminotransferase	21 (13.5-33.525)	17 (12.47-24)		-1.502	0.133
Aspartate aminotransferase	21.9 (17-27.5)	20 (17-22.03)		-1.251	0.211
Total bilirubin	12.715 (7.9225-14.9)	10.58 (8.25-13.78)		-1.274	0.203
Creatinine	45.6 (41.465-48.8)	45.4 (42.8-49.5)		-0.234	0.815
Urea Nitrogen	4.69 (4.3-5.1218)	5.1 (4.12-5.9)		-1.485	0.138
Race				-1.400	0.161
Marital status				-0.323	0.747
Profession				-0.999	0.318
Education				-0.467	0.640
Household income level (in recent year)				-0.050	0.960
Resident population (in recent year)				-1.272	0.203
Medical procedures				-0.475	0.635
Whether the patient has hypertension				-0.499	0.618
Whether the patient has diabetes				-0.988	0.323
Whether the patient ever had heart disease				-0.020	0.984
Whether the patient has other tumors				-0.566	0.571
Whether the patient has a long-term medication history				-0.823	0.410
Whether the patient has a smoking history				-1.010	0.313
Whether the patient has a drinking history				0.000	1.000
Whether the patient has the habit of taking health products				-1.036	0.300
Attitude				-1.293	0.196
Character traits				-2.479	0.013
Facing major events in life				-3.258	0.001
Attitude to this matter (suffering from breast cancer)				-2.654	0.008
Whether the patient has undergone surgery				-1.364	0.172
Surgical approach				-0.543	0.587
Chemotherapy administration				-1.344	0.179
Chemotherapy regimen				-1.143	0.253

PLD: Pegylated liposomal doxorubicin; BMI: Body mass index.