Clinical management and susceptibility of primary hepatic lymphoma: A cases-based retrospective study

Table 4 Univariate and multivariate Cox regression for analyzing the risk factors for primary hepatic lymphoma patients

Variables	Univariate			Multivariate
	HR	95%CI	P value	Adjusted HR	95%CI	P value
Sex
Female	Ref.
Male	1.442	0.582-3.574	0.429	NA	NA	NA
Age (years)
< 60	Ref.
≥ 60	1.101	0.468-2.593	0.825	NA	NA	NA
Virus infection
Unknown	Ref.
Yes	1.009	0.370-2.756	0.985	NA	NA	NA
LDH
Normal	Ref.			Ref.
Elevated	3.023	1.172-7.797	0.022	1.901	0.667-5.416	0.229
Liver function
Normal	Ref.			Ref.
Abnormal	2.747	1.108-6.813	0.030	1.333	0.477-3.730	0.584
B symptom
No	Ref.			Ref.
Yes	2.810	1.090-7.246	0.032	1.785	0.654-4.872	0.258
Hepatosplenomegaly
No	Ref.			Ref.
Yes	2.971	1.152-7.663	0.024	1.925	0.697-5.466	0.203
Lesion
Single	Ref.			Ref.
Multiple or diffused	2.743	1.064-7.075	0.037	1.992	0.753-5.276	0.165

HR: Hazard ratio; CI: Confidence interval; LDH: Lactate dehydrogenase; NA: No application.