Retrospective analysis of surgically treated pT4b gastric cancer with pancreatic head invasion

Table 3 Univariate and multivariate analysis of prognostic factors for pT4 gastric cancer with pancreatic head invasion

Variable	Univariate analysis		Multivariate analysis
					HR (95%CI)
	P value	HR (95%CI)	P value
Age ≥ 65/< 65 yr	1.19 (0.567–2.505)	0.644	—	—
Gender (male/female)	1.01 (0.369–2.101)	0.346	—	—
Preoperative hemoglobin < 35 g/L (yes/no)	1.09 (0.423–3.205)	0.524	—	—
Preoperative anemia	1.18 (0.523–2.985)	0.502	—	—
(hemoglobin < 90 g/L) (yes/no)
Neoadjuvant chemotherapy (yes/no)	0.180 (0.073–0.446)	< 0.001	0.29 (00.103–0.821)	0.02
Operation type (GP/GA)	0.393 (0.188–0.819)	0.013	0.689 (0.157–3.019)	0.621
Borrmann type		0.159	—	—
I	1
II	1.399 (0.266–7.358)	0.692
III	0.479 (0.164–1.403)	0.179
IV	0.398 (0.144–1.100)	0.076
Tumor diameter > 7/≤ 7 cm	0.380 (0.190–0.758)	0.006	—	—
Tumor type (linitis plastica/not)	2.764 (1.127–6778)	0.026	2.614 (1.024–6.675)	0.033
Intraoperative blood loss > 400mL (yes/no)	1.089 (0.347–2.102)	0.154
Operation time > 240 min	1.021 (0.233–3.112)	0.423
Surgical margin (R0/R1)	2.501 (1.177–5.314)	0.017	0.274 (0.102–0.738)	0.01
Lymphovascular invasion (yes/no)	2.512 (1.066–5.921)	0.035	1.517 (0.930–2.476)	0.095
Perineural invasion (yes/no)	1.545 (0.781–3.054)	0.211	—	—
Differentiation type (poor/well–moderate)	1.358 (0.610–3.021)	0.454	—	—
N stage(N0/N1/N2/N3a/N3b)	1.708 (1.103–2.644)	0.016	3.489 (1.334–9.120)	0.011
Postoperative treatment (chemotherapy/chemoradiotherapy)	0.347 (0.159–0.757)	0.008	0.369 (0.163–0.836)	0.017

HR: Hazard ratio; CI: Confidence interval; GP: Gastrectomy combined with pancreatectomy; GA: Gastrectomy alone.