Cost-effective screening using a two-antibody panel for detecting mismatch repair deficiency in sporadic colorectal cancer

Table 3 Validity of 4- and 2-antibody panels in immunohistochemistry based on a microsatellite instability test

	4-antibody IHC	2-antibody IHC
		PMS2/ MSH6	MLH1/MSH2
Sensitivity (95%CI)	97.4%(93.7-99.0)	92.2%(87.3-95.4)	87.6%(81.9-91.7)
Specificity (95%CI)	99.6%(99.3-99.8)	99.6%(99.3-99.8)	99.7%(99.5-99.9)
κ	0.952	0.923	0.906

CI: Confidence interval; κ: Cohen's kappa statistic (value of kappa ≥ 0.90, almost perfect agreement)[10]. IHC: Immunohistochemistry.