Cost-effective screening using a two-antibody panel for detecting mismatch repair deficiency in sporadic colorectal cancer

doi:10.12998/wjcc.v9.i24.6999

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World Journal of Clinical Cases

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Clin Cases. Aug 26, 2021; 9(24): 6999-7008
Published online Aug 26, 2021. doi: 10.12998/wjcc.v9.i24.6999

Table 1 Clinicopathological characteristics according to microsatellite instability (n = 3486)

Characteristics		MSS	MSI-H	P value
n (%)		3293 (94.5)	193 (5.5)
Sex	Male	1958 (59.5)	106 (54.9)	0.213
	Female	1335 (40.5)	87 (45.1)
Age (mean ± SD, yr)		62.37 ± 11.68	59.84 ± 15.36	< 0.001
	≤ 50	513 (15.6)	56 (29.0)
	> 50	2780 (84.4)	137 (71.0)
CEA (median ± IQR)		2.4 ± 1.4-5.3	2.1 ± 1.1-5.4	0.630
	< 6 ng/mL	2515 (77.1)	142 (75.5)
	≥ 6 ng/mL	749 (22.9)	46 (24.5)
Location	Right colon	767 (23.3)	145 (75.1)	< 0.001
	Left colon	989 (30.0)	31 (16.1)
	Rectum	1537 (46.7)	17 (8.8)
pT	T0 /T1/T2	828 (25.1)	47 (24.4)	0.805
	T3/T4	2465 (74.9)	146 (75.6)
pN	N0	1765 (53.6)	142 (73.6)	< 0.001
	N1/N2	1526 (46.4)	51 (26.4)
pM	M0	2742 (83.3)	185 (95.9)	< 0.001
	M1	551 (16.7)	8 (4.1)
Differentiation grade	WD/MD	3022 (95.2)	138 (81.2)	< 0.001
	PD/MA	154 (4.8)	32 (18.8)
LVI	No	1782 (54.2)	133 (69.3)	< 0.001
	Yes	1504 (45.8)	59 (30.7)
PNI	No	2299 (70.2)	169 (88.5)	< 0.001
	Yes	977 (29.8)	22 (11.5)

MSS: Microsatellite stable; MSI-H: High-frequency microsatellite instability; SD: Standard deviation; CEA: Carcinoembryonic antigen; IQR: Interquartile range; pT: Pathological tumor stage; pN: Pathological nodal stage; pM: Pathological metastatic stage; WD: Well-differentiated adenocarcinomas; MD: Moderately-differentiated adenocarcinomas; PD: Poorly-differentiated adenocarcinomas; MA: Mucinous adenocarcinomas; LVI: Lymphovascular invasion; PNI: Perineural invasion.

Citation: Kim JB, Kim YI, Yoon YS, Kim J, Park SY, Lee JL, Kim CW, Park IJ, Lim SB, Yu CS, Kim JC. Cost-effective screening using a two-antibody panel for detecting mismatch repair deficiency in sporadic colorectal cancer. World J Clin Cases 2021; 9(24): 6999-7008
URL: https://www.wjgnet.com/2307-8960/full/v9/i24/6999.htm
DOI: https://dx.doi.org/10.12998/wjcc.v9.i24.6999