Innate immunity – the hallmark of Helicobacter pylori infection in pediatric chronic gastritis

Table 1 Demographic analysis of the two groups, n (%)

Parameters	Study group, n = 48	Control group, n = 107	P value
Age in yr	12.96 ± 3.83 (13.50)	12.09 ± 3.80 (12.00)	0.1987
Gender
Girls	29 (60.42)	62 (57.94)	0.7725
Boys	19 (39.58)	45 (42.06)
Originating area
Urban	15 (31.25)	60 (56.07)	0.0042
Rural	33 (68.75)	47 (43.93)
TLR9 rs352140
CT genotype	21 (43.75)	63 (58.88)	0.1075
TT genotype	16 (33.33)	20 (18.69)
CC genotype	11 (21.92)	24 (22.43)
Family history
Negative	47 (97.92)	106 (99.07)
Positive	1 (2.08)	0 (0.00)
Living conditions
Good	31 (64.59)	99 (92.52)	< 0.0001
Poor	17 (36,41)	8 (7.48)
IgA anti-Helicobacter pylori
Positive	30 (62.50)	3 (2.80)	< 0.0001
Negative	17 (36, 41)	104 (97.20)
Gastro-esophageal reflux
Present	9 (18.75)	25 (23.36)	0.6657
Absent	39 (81.25)	82 (76.64)
Biliary reflux
Present	12 (25)	31 (28.97)	0.6096
Absent	36 (75)	76 (71.03)
Rapid urease test
Positive	31 (64.58)	15 (15.01)	< 0.0001
Negative	17 (35.42)	91 (85.05)

CC: Homozygous wild-type genotype; TT: Homozygous variant genotype.