Bone marrow inhibition induced by azathioprine in a patient without mutation in the thiopurine S-methyltransferase pathogenic site: A case report

Figure 3 The results of the bone marrow biopsy. A: Results of bone marrow aspiration-myelogram. The myelogram showed low myelodysplasia (G = 52.0%, E = 25.0%, G/E = 2.1/1); cells in the lower and middle granulocyte stages were observed, with a low proportion of mesoblastic granulocytes and a high proportion of lobulated nuclei, with obvious abnormal morphology. Cells in the lower erythroid stage could be seen with a higher proportion of late immature red cells, smaller cell bodies, different sizes of mature red cells, and some hollow enlargement. No obvious abnormality was found in lymphocytes; only one naked nucleus was found in the whole sample, with few platelets and no parasites; B: Bone marrow biopsy showed focal hyperplasia in some areas (70%) and normal hyperplasia in some areas (40%). The proportion of granulocyte red staining was generally normal. Cells at various granulocyte stages were visible, mainly in the middle and late juvenile stage; there were many megakaryocytes, mainly with lobulated nuclei, and some megakaryocytes were less abundant. Reticular fiber staining: Mf0 grade iron staining: Negative.