Pancreatic neuroendocrine carcinoma in a pregnant woman: A case report and review of the literature

Table 1 Summary of pancreatic neuroendocrine neoplasms in pregnancy (2000-2019)

Ref.	Patient age	Onset of symptoms	Symptoms	Management	Maternal outcomes	Fatal outcomes
Fredericks et al[19]	35-yr-old	Three weeks post-partum	Neuroglycopaenic symptoms	Laparotomy the tumor	No symptoms after removal	Live born
Takacs et al[20]	28-yr-old	At 6-wk gestation	Difficult morning arousability	Exploratory laparotomy	No residual symptoms	Cesarean delivery
						Live born
Lowy and Chisholm[23]	36-yr-old	Twelve hours post-partum	Severe hypoglycaemia	Excision of the lesion	No symptoms after removal	Live born
Diaz et al[24]	35-yr-old	Three months	Loss of consciousness	Exploratory laparotomy	No residual symptoms	Live born
		Post-partum
Diaz et al[24]	35-yr-old	On the 26th postpartum day	Confusion, dysarthria, and quadriplegia	Enucleation of an 8-mm tumor	No symptoms after removal	Live born
Diaz et al[24]	22-yr-old	At 2-mo gestation	Loss of consciousness	Laparoscopic distal pancreatectomy	No residual symptoms	Natural labor
				Post-partum		Live born
Christiansen and Vestergaard[25]	29-yr-old	At 38-mo gestation	Slurred speech, weakness	Pancreaticoduodenectomy and cholecystectomy	No symptoms after removal	Natural labor
				Post-partum		Live born
Rodrigues Queiróz et al[26]	21-yr-old	Eight days post-partum	Four limbs weahness, diffic-ult walking	Pancreatectomy	No residual symptoms	Live born
Mannelli et al[27]	29-yr-old	At 17 wk gestation	Severe hypoglycemia	Started therapy with everolimus	Died 3 yr after delivery	Cesareandelivery
						Live born
Tomazic et al[28]	36-yr-old	In the second trimester of pregnancy	Hypoglycemia associated with neuroglycopenic symptoms	Distal pancreatectomy at 21 wk gestation	No symptoms after removal	Nature labor
						Live born