Pediatric Wilson disease presenting as acute liver failure: Prognostic indices

Table 4 Sensitivity, specificity, and positive and negative predictive values of different mortality-predicting models using their original cutoff values in our pediatric patients with Wilson disease with acute liver failure

	KCHC			MELD/PELD			LIU-PT			LIU-INR			aLIU-PT			aLIU-INR			Devarbhavi model
Cutoff values	< 11	≥ 11	P	< 30	≥ 30	P	< 153	≥ 153	P	< 297	≥ 297	P	< 173	≥ 173	P	< 212	≥ 212	P	< 10.4	≥ 10.4	P
Death (n)	0	3	0.034a	0	3	0.004a	0	3	0.013a	0	3	0.013a	0	3	0.04a	0	3	0.031a	0	3	0.02a
Survival (n)	25	10		31	4		29	7		29	7		25	11		26	10		27	8
Sensitivity			1.000			1.000			1.000			1.000			1.000			1.000			1.000
Specificity			0.714			0.886			0.806			0.806			0.694			0.722			0.771
PPV			0.231			0.429			0.300			0.300			0.214			0.231			0.273
NPV			1.000			1.000			1.000			1.000			1.000			1.000			1.000

^aP value < 0.05. aLIU: Admission to Liver Injury Unit; KCHC: King’s College Hospital Criteria; LIU: Liver Injury Unit; MELD/PELD: Model for end-stage liver disease/pediatric end-stage liver disease; NPV: Negative predictive value; PPV: Positive predictive value.