Early renal injury indicators can help evaluate renal injury in patients with chronic hepatitis B with long-term nucleos(t)ide therapy

Table 2 Examination results of patients in different estimated glomerular filtration rate value groups

eGFR value [mL/(min·1.73 m2)]	≥ 90, n = 22	60-89, n = 42	30-59, n = 5
Age in yr	46.8 ± 11.4	58.3 ± 11.9	69.6 ± 16.101
Sex as M/F	18/4	27/15	3/2
Antiviral treatment time in mo	84.0 ± 30.9	111.1 ± 39.2	96.8 ± 38.12
ALT in IU/L	33.36 ± 16.83	22.31 ± 10.35	21.80 ± 10.32
Creatinine in µmol/L	74.71 ± 9.98	86.20 ± 12.83	107.4 ± 12.543
BUN in mmol/L	4.56 ± 1.17	5.38 ± 1.40	6.32 ± 1.494
Cases of increased BUN	0	3 (7.1%)	3 (60%)5
Blood phosphorus in mmol/L	0.94 ± 0.16	1.01 ± 0.15	0.86 ± 0.206
Cases of decreased blood phosphorus	4 (18.2%)	7 (16.7%)	2 (40%)
Cases of early renal injury	8 (36.4%)	20 (47.6%)	3 (60%)
Cases of abnormal urine microalbumin	3 (13.6%)	4 (9.5%)	1 (20%)
Cases of abnormal urine transferrin	1 (4.5%)	5 (11.9%)	0
Cases of abnormal NAG enzyme	5 (22.7%)	8 (19.0%)	1 (20%)
Cases of abnormal α1 microglobulin	5 (22.7%)	11 (26.2%)	3 (60%)
Cases of abnormal urine immunoglobulin	1 (4.5%)	5 (11.9%)	1 (20%)

Comparison among the three groups.

¹Indicates K = 14.979, P = 0.001.

²Indicates K = 7.623, P = 0.022.

³Indicates K = 19.034, P = 0.000.

⁴Indicates comparison between the third group and the first group, t = 2.575, P = 0.012.

⁵Indicates Fisher’s exact test without chi-square value, P = 0.011.

⁶Indicates comparison between the third group and the second group, t = 2.045, P = 0.047. ALT: Alanine aminotransferase; BUN: Serum urea nitrogen; eGFR: Estimated glomerular filtration rate; F: Female; M: Male; NAG: N-acetyl-β-D-glucosidase.