Early renal injury indicators can help evaluate renal injury in patients with chronic hepatitis B with long-term nucleos(t)ide therapy

Table 1 Renal function test results of patients with and without adefovir dipivoxil / tenofovir disoproxil fumarate treatment

Treatment group	Increased BUN	Early renal damage	eGFR ≥ 90	eGFR 89-60	eGFR 59-30	Hypophosphatemia
ADV/TDF group, n = 25	3 (12%)	151 (60%)	6 (24%)	16 (64%)	3 (12%)	6 (24%)
Non-ADV/TDF group, n = 44	3 (6.8%)	16 (36.4%)	16 (36.4%)	26 (59.1%)	2 (4.5%)	7 (15.9%)

¹Compared with the non-ADV/TDF treatment group, χ² = 3.600, P = 0.057. ADV: Adefovir dipivoxil; BUN: Serum urea nitrogen; eGFR: Estimated glomerular filtration rate; TDF: Tenofovir disoproxil fumarate.